Process for preparing integrin antagonist intermediate

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S350000

Reexamination Certificate

active

06914144

ABSTRACT:
A process is provided for the preparation of 2,5-di-(3′-aminopropyl)pyridine which is useful in the synthesis of αvβ3 integrin receptor antagonists. Also provided are useful intermediates obtained from the process.

REFERENCES:
patent: 6017926 (2000-01-01), Askew et al.
patent: 6262268 (2001-07-01), Palucki et al.
patent: 6262286 (2001-07-01), Gregorius et al.
Palucki, et al., Tetrahedron Letters, vol. 42, No. 39, 2001) “A highly efficient synthesis of 2-[3-aminopropyl]-5m6,7,8-tetrahydronaphthyridine via a double Suzuki reaction and a Chichibabin cyclization”, pp. 6811-6814.

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