Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-07-19
2005-07-19
Priebe, Scott D. (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S006120, C435S320100, C435S456000
Reexamination Certificate
active
06919208
ABSTRACT:
The present invention relates to methods and compositions useful for enhancing the efficiency of delivery of a nucleic acid to a cell. Preferably the cell is a mammalian cell. The method comprises providing to a cell an agent capable of enhancing the cytoskeletal permissiveness of the cell for transfection. The method also comprises providing to the cell a nucleic acid delivery system for the transfection of the cell, whereby the efficiency of delivery of a nucleic acid to the cell is enhanced. Compositions and kits for enhancing the efficiency of delivery of a nucleic acid to a cell are also included
REFERENCES:
patent: WO 99/34831 (1999-07-01), None
patent: WO 01/51092 (2001-07-01), None
Schneider et al. “Targeted gene delivery into alpha-9 beta-1-integrin-displaying cells by a synthetic peptide,” FEBS Letters 458 (3): 329-332, Sep. 24, 1999.
Shih et al., “Matrigel treatment of primary hepatocytes following DNA transfection enhances responsiveness to extracellular stimuli,” Biotechniques 18 (5): 813, 814, 816, May 1995.
Grant et al., “Matrigel induces thymosin beta-4 gene in differentiating endothelial cells,” J. Cell Sci. 108 (Pt. 12): 3685-3694, Dec. 1995.
Watanabe et al., “Highly efficient transfection into primary cultured mouse hepatocytes by use of cation-liposomes: an application for immunization,” J. Biochem. 116 (6): 1220-1226, Dec. 1994.
Pasco et al., “Efficient DNA-mediated gene transfer into primary cultures of adult rat hepatocytes,” DNA 8 (7): 535-541, Sep. 1989.
Orkin et al. “Report and recommendations of the panel to assess the NIH investment in research on gene therapy,” issued by US National Institutes of Health, Bethesda, MD, Dec. 7, 1995.
Fasbender, et al., “Complexes of Adenovirus with Polycationic Polymers and Cationic Lipids Increase the Efficiency of Gene Transfer in Vitro and in Vivo,”The Journal of Biological Chemistry, vol. 272, No. 10, pp. 6479-6489 (1997), The American Society for Biochemistry and Molecular Biology, Inc., USA.
Uhlmann, et al., “Chemical Reviews,”Antisense Oligonucleotides: A New Therapeutic Principle, vol. 90, No. 4, pp. 544-584 (1990), The American Chemical Society, USA.
Schneider, et al., “Building Blocks for Oligonucleotide Analogs with Dimethylene-Sulfide,-Sulfoxide, and -Sulfone Groups Replacing Phosphodiester Link Ages,” Tetrahedron Letters, vol. 31, No. 3, pp. 335-338 (1990), Pergamon Press plc, UK.
Low, et al., “Complete amino acid sequence of bovine thymosin β4: A thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations,”Proc. Natl. Acad. Sci., vol. 78, No. 2, pp. 1162-1166, (1981), Immunology, USA.
Safer, et al., “Isolation of a 5-kilodalton actin-sequestering peptide from human blood platelets,”Proc. Natl. Acad. Sci., vol. 87, pp. 2536-2540, (1990), Cell Biology, USA.
Low, et al., “Thymic Hormones and Peptides,”Methods in Enzymology, vol. 116, pp. 248-255, (1985), Academic Press, USA.
Nachmias, et al., “Small actin-binding proteins: the β-thymosin family,”Cell Biology, vol. 5, pp. 56-62 (1993), Current Biology Ltd, USA.
Bradke, et al., “The Role of Local Actin Instability in Axon Formation,”Science, vol. 283, pp. 1931-1934 (1999), American Association for the Advancement of Science, USA.
Cooper, et al., “Effects of Cytochalasin and Phalloidin on Actin,”The Journal of Cell Biology, vol. 105, pp. 1473-1478, (1987) The Rockefeller University Press, USA.
Orkin, et al., “Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy,” pp. 1-49 (1995), National Institute of Health, USA.
Indar, et al., “Current concepts in immunotherapy for the treatment of colorectal cancer,”J.R. Coll. Edinb., vol. 47, pp. 458-474 (2002), The Royal College of Surgeons of Edinburgh, Great Britain.
De Kleijn, et al., “Biological therapy of colorectal cancer,”European Journal of Cancer, vol. 38, pp. 1016, 1022 (2002), Pergamon Press, The Netherlands.
Behr, et al., “Radioimmunotherapy of Small-Volume Disease of Metastatic Colorectal Cancer,”Cancer, vol. 94, No. 4, pp. 1373-1381 (2002), American Cancer Society, USA.
Stein, et al., “Combining Radioimmunotherapy and Chemotherapy for Treatment of Medullary Thyroid Carcinoma,”Cancer, vol. 94, No. 1, pp. 51-61 (2002), American Cancer Society, USA.
Behr, et al., “Improved Treatment of Medullary Thyroid Cancer in a Nude Mouse Model by Combined Radioimmunotherapy: Doxorubicin Potentiates the Therapeutic Efficacy of radiolabeled Antibodies in a Radioresistant Tumor Type,”Cancer Research, vol. 57, pp. 5309-5319 (1997), American Association for Cancer Research, USA.
Stein, et al., “Carcinoembryonic Antigen as a Target for Radioimmunotherapy of Human Medullary Thyroid Carcinoma: Antibody Processing, Targeting, ad Experimental Therapy with131I and90Y Labeled Mabs,”Cancer Biotherapy&Radiopharmaceuticals, vol. 14, No. 1, pp. 37-47 (1999), Mary Ann Liebert, Inc., USA.
Kinuya, et al., “Efficacy, toxicity and mode of interaction of combination radioimmunotherapy with 5-fluorouacil in colon cancer xenografts,”J Cancer Res Clin Oncol, vol. 125, pp. 630-636 (1999), Springer-Verlag, Germany.
Juweid, et al., “Phase I/II Trial of131I-MN-14 (F(ab)2Anti-Carcinoembryonic Antigen Monoclonal Antibody in the Treatment of Patients with Metastatic Medullary Thyroid Carcinoma,”American Cancer Society, vol. 85, pp. 1828-1842, (1999).
Juweid, et al., “Prospects of Radioimmunotherapy in Epithelial Ovarian Cancer: Results with Iodine-131-Labeled Murine and Humanized MN-14 Anti-carcinoembryonic Antigen Monoclonal Antibodies1,”Gynecologic Oncology, vol. 67, pp. 259-271 (1997) Article No. G0974870, Academic Press, USA.
Spiller, et al., “Improving the Intracellular Delivery and Molecular Efficacy of Antisense Oligonucleotides in Chronic Myeloid Leukemia Cells: A Comparison of Streptolysin-O Permeabilization, Electroporation, and Lipophilic Conjugation,”Blood, vol. 91, No. 12, pp. 4738-4746 (1996), The American Society of Hematology, USA.
Muhlrad, et al., “Dynamic Properties of Actin,”The Journal of Biological Chemistry, vol. 269, No. 16, pp. 11852-11858 (1994), The Journal of Biological Chemistry, USA.
Wang, et al., “Cellular Factors Mediate Cadmium-Dependent Actin Depolymerization,”Toxicology and Applied Pharmacology, vol. 139, pp. 115-121 (1996), Academic Press, Canada.
Jones Peter L.
Levy Robert J.
Li Quanyi
Dann Dorfman Herrell and Skillman
Priebe Scott D.
The Children's Hospital of Philadelphia
LandOfFree
Methods and compositions for enhancing the delivery of a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for enhancing the delivery of a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for enhancing the delivery of a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3375231