Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-09-13
2005-09-13
Celsa, Bennett (Department: 1639)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S300000, C530S317000, C530S324000, C530S409000
Reexamination Certificate
active
06943145
ABSTRACT:
The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The peptide derivatives, which comprise a dihydropyridinepyridinium salt-type redox targetor moiety, a bulky lipophilic function and an amino acid/dipeptide/tripeptide spacer, are used in the prevention and treatment of diabetic retinopathy.
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Bodor,S.T.P. Pharma Sci., “Brain targeting of drugs and neuropeptides by retrometabolic design approaches”, 7(1), pp. 43-52 (1997).
Bodor Nicholas Stephen
Grant Maria Bartolomeo
Celsa Bennett
Reusse Brownlee Wolter Mora & Maire
University of Florida
Van Dyke Timothy H.
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