Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-07-26
2005-07-26
Riley, Jezia (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024300, C536S025300
Reexamination Certificate
active
06921812
ABSTRACT:
2′-O-(2-Methylthioethyl), has been incorporated into oligonucleotides and evaluated for antisense properties in comparison with the known 2′-O-(2-methoxyethyl) 2′-O-MOE modification. The 2′-O-MTE modified oligonucleotides exhibit improved binding to human serum albumin compared with the 2′-O-MOE modified oligonucleotides and maintain high binding affinity to target RNA.
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Manoharan Muthiah
Prakash Thazha P.
Isis Patent Department
ISIS Pharmaceuticals Inc.
Riley Jezia
Woodcock & Washburn LLP
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