Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands

Details Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands

2005-05-03

2005-05-03

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S252040, C514S255050, C514S256000, C546S118000, C544S238000, C544S398000, C544S322000, C544S333000, C544S405000

Reexamination Certificate

active

06887885

ABSTRACT:
A compound of formula I, or a pharmaceutically acceptable salt thereof:whereinX1represents hydrogen, halogen, C1-6alkyl, trifluoromethyl or C1-6alkoxy;X2represents hydrogen or halogen;Y represents a chemical bond, an oxygen atom, or a —NH— linkage;Z represents an optionally substituted aryl or heteroaryl group;R1represents hydrocarbon, a heterocyclic group, trifluoromethyl, —SO2Ra, —SO2NRaRb, —CORa, —CO2Raor —CONRaRb; andRaand Rbindependently represent hydrogen, hydrocarbon or a heterocyclic group;pharmaceutical compositions including the compound and methods for treating anxiety, convulsions and cognitive disorders are disclosed.

REFERENCES:
patent: WO 0040583 (2000-07-01), None

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