Dicarba-closo-dodecarborane derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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Details

C560S041000, C560S102000, C560S106000, C562S473000, C562S475000, C562S491000, C562S433000, C562S455000, C568S004000, C514S569000

Reexamination Certificate

active

06838574

ABSTRACT:
A medicament comprising as an active ingredient a compound or a physiologically acceptable salt thereof represented by general formula (I):wherein R1represents a dicarba-closo-dodecaboran-yl which may be substituted with a lower alkyl group, a lower alkenyl group, carboxyl group or the like; R2represents carboxyl group, a lower alkoxycarbonyl group, or hydroxyl group; and X represents a single bond or a linking group such as —CO—Y1— wherein Y1represents oxygen or —N(R3)— wherein R3represents hydrogen or a lower alkyl.

REFERENCES:
patent: 4824659 (1989-04-01), Hawthorne
patent: 0205326 (1986-12-01), None
patent: 55154982 (1980-12-01), None
patent: 5-163296 (1993-06-01), None
Fox, M.A. et al., “Transmission of electronic effects by icosahedal carboranes; skeletal carbon-13 chemical shifts and ultraviolet-visible spectra of substituted arly-p-carboranes (1,12-dicarba-closo-dodecaboranes)”, J. Chem. Soc., Dalton Trans., No. 3, pp. 401-411 (1998).
Colquhoun H.M. et al., “Polyetherketones based on para-carborane: synthesis, sulfonation, and membrane-forming characteristics”, Polymer, vol. 38, No. 17, pp. 4539-4546 (1997).
Prashar J.K. et al., “Synthesis of Carboranyl Phenylalanine for potential us in neutron capture therapy of melanoma”, J. Chem. Soc. Perkin. Trans., No. 9, pp. 1051-1053 (1993).
Brown D.A. et al., “Polymers and ceramics based on icosahedral carbranes, model studies of the formation an dhydrolytic stability of aryl ether, ketone, amide, and borae linlakages between carborane units”, J. Mater. Chem., vol. 2, No. 8, pp. 793-804 (1992).
Nemoto H. et al., “The first alkylation of o-carbonranes under essentially neutral conditions. Aplication to the synthesis of B carriers”, J. Org. Chem., vol. 55, No. 25, pp. 6065-6066 (1990).
Chemical Abstracts, vol. 89, No. 196733.
Chemical Abstracts, vol. 89, No. 6351.
Matochkin V.S. et al., “Molecular mobility in polyarylates having difenylcarborane fragments in the chain”, Faserforsch. Textiltech., Bol. 26, No. 6, pp. 261-265 (1975).
Chemical Abstracts, vol. 82, No. 17164.
Valetskii P.M. et al., “Polyamides of 1,7-bis (p-carbosy-phenyl) carborane”, Vysokomol. Soedin., Ser. A, vol. 15, No. 6, pp. 1227-1233 (1973).
Chemical Abstracts, vol. 76, No. 46645.
Chemical Abstracts, vol. 65, No. 98063.
Zakharkin L.I. et al., “Ionization constants of 1-(p-and m-carboxyphenyl)-2-substituted o-carboranes”, Xh. Obshch. Khim., vol. 41, No. 6, pp. 1300-1303 (1971).
Chemical Abstracts, vol. 71, No. 39047.
Chemical Abstracts, vol. 68, No. 39684.
Zh. Obshch. Khim., vol. 41, pp. 1516-1520 (1971).
Chemical Abstracts, Vo. 75, No. 98063.
English Language Abstract of JP 5-163296, Jun. 29, 1997.
English Language Abstract of JP 55-154982, Feb. 12, 1980.
Endo Y. et al., “Structure-activity study of estrogenic agonists bearing dicarba-closo-dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules”, Bioorg. Med. Chem. Lett., vol. 9, No. 23, pp. 3313-3318 (1999).
Endo Y. et al., “Estrogenic antagonists bearing sicarba-closo-dodecaborane as a hydrophobic pharmacophore”, Bioorg. Med. Chem. Lett., vol. 9, No. 24, pp. 3387-3392 (1999).
Endo Y. et al., “Potent estrogenic agonists bearing dicarba-closo-dodecaborane as a hydrophobic Pharmacophore”, J. Med. Chem., vol. 42, No. 9, pp. 1501-1504 (1999).
Endo Y et al., “Dicarba-closo-dodecaboranes as pharmacophore. Novel potent retinoidal agonists”, Cham. Pharm. Bull., vol. 47, No. 4, pp. 585-587 (1999).
Iijima T. et al., “Dicarba-closo-dodecaboranes as a pharma-cophore. Retinoidal antagonists and potential agonists”, Chem. Pharm. Bull., vol. 47, No. 3, pp. 398-404 (1999).
Chemical Abstracts, vol. 66, No. 95101.
Chemical Abstracts, vol. 65, Par. No. 16989,f-g.
Chemical Abstracts, vol. 65, Par. No. 10604,g-h.
Chemical Abstracts, vol. 64, Par. No. 11235,d-h.
Chemical Abstracts, vol. 63, Par. No. 17865,f-h.

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