Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2001-08-30
2004-02-17
Patterson, Jr., Charles L. (Department: 1652)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S423000, C514S477000
Reexamination Certificate
active
06692754
ABSTRACT:
TECHNICAL FIELD
The present invention relates to skin aging inhibitors and/or skin quality-improving agents, and cosmetic compositions having the activities to inhibit the skin aging and to improve the skin quality containing said skin aging inhibitors and/or skin quality-improving agents.
BACKGROUND ART
Aging preventive materials have so far been broadly employed in cosmetics for the purpose of attaining beauty effect for preventing skin aging or deterioration of skin quality which causes skin troubles such as wrinkles, bags, dry skin, etc.
The aging preventive materials employed in cosmetics are broadly classified into peroxide lipid inhibitors and cell activators. Examples of the materials having the activity to inhibit peroxide lipid are &agr;-hydroxy acids, vitamin A, &bgr;-carotene, vitamin B
12
, vitamin E, pigments such as plarutin and platonin, scutellaria root, rutin, sesame extract, and tea extract, etc. On the other hand, examples of the cell activators are muminequis, glycolic acid, &ggr;-amino acid, sialic acid, royal jerry, extract of Swertia japonica (Schult.) Makino, Japanese chirata, ginseng extract, etc.
It is known that the cell activators include materials which promote collagen synthesis and materials having the activity to improve skin quality.
Examples of the materials which promote collagen synthesis include various growth factors such as transforming growth factor &bgr;1, platelet-derived growth factor, basic fibroblast growth factor and insulin-like growth factor 1, etc. and silk protein, etc.
Examples of the materials having the activity to improve the skin quality include allantoin, aloe extract, ginseng extract, placenta extract, bovine blood freed of protein, fermentation metabolites, and so on.
There is a report that hydroxyproline derivatives are used as components of cosmetics to keep the skin elasticity by increasing the oxygen consumption of disrupted mouse liver. (JP, 1-131107, A) However, the report contains neither description of the relationship between the increase in oxygen consumption of disrupted mouse liver and the effect on the human skin nor data concerning the effectiveness of compounds as components of cosmetics. Accordingly, it is not possible to conclude from the report that the hydroxyproline derivatives are effective as components of cosmetics. There has been no report showing that hydroxyproline or its derivatives are effective as cosmetics.
For the purpose of enhancing moisture retention effect, there are reports on cosmetics comprising mucin (JP, 5-339140, A) or glycine betaine and pyrrolidonecarboxylic acid or its salt (JP, 9-87126, A) in combination with amino acids. In the reports, hydroxyproline is mentioned as an example of amino acids, but no data is given concerning the effect of cosmetics comprising hydroxyproline.
In this way, any function and effect of hydroxyproline and its N-acyl derivatives to skin in the cosmetic field is unknown.
It is not known that hydroxyproline and its N-acyl derivatives show an activity to promote the proliferation of epidermal cells and an activity to promote the collagen synthesis in fibroblast. Further, any cosmetics utilizing said activity has not been known yet.
In addition, any cosmetics made of hydroxyproline manufactured by using a microorganism have never been known so far.
DISCLOSURE OF THE INVENTION
An object of the present invention is to provide skin aging inhibitors and/or skin quality-improving agents having the activity to inhibit the skin aging and/or the activity to imporve the skin quality, such as epidermis proliferation promoters, fibroblast collagen-synthesis promoters, epidermis moisture retention function-improving agents, and to provide cosmetic compositions having the activity to inhibit the skin aging and/or the activity to improve the skin quality containing said skin aging inhibitors and/or skin quality-improving agents.
An object of the present invention is to provide a method of inhibiting skin aging and/or improving skin quality which comprises applying onto skin a skin aging inhibitor and/or skin quality-improving agent containing hydroxyproline, its N-acyl derivative or salts thereof as an effective ingredient.
Another object of the present invention is to provide a method of inhibiting skin aging and/or improving skin quality which comprises applying skin aging inhibiting cosmetic compositions and/or skin quality-improving cosmetic compositions containing hydroxyproline, its N-acyl derivative or salts thereof as an effective ingredient onto skin.
A further object of the present invention is to provide use of hydroxyproline, its N-acyl derivative or salts thereof for producing skin aging inhibitors and/or skin quality-improving agents.
An object of the present invention is to provide use of hydroxyproline, its N-acyl derivative or salts thereof for producing cosmetic compositions having the activity to inhibit skin aging and/or to improve skin quality.
Another object of the present invention is to provide use of hydroxyproline, its N-acyl derivative or salts thereof for inhititing skin aging and/or improving skin quality.
As the result of keen investigations for cosmetics with high safety having moisture keeping effect, skin aging-inhibiting activity and skin quality-improving activity, the present inventors have found that hydroxyproline or N-acyl derivatives thereof shows such the effect, and thus, the present invention has been completed.
Accordingly, the present invention relates to the following features (1)-(68).
(1) Skin aging inhibitors and/or skin quality-improving agents, comprising hydroxyproline, N-acylated hydroxyproline derivatives or salts thereof.
(2) The skin aging inhibitors and/or skin quality-improving agents according to (1), wherein the amount of said hydroxyproline or N-acylated hydroxyproline derivatives is 0.01 to 5 wt % based on the total weight.
(3) The skin aging inhibitors and/or skin quality-improving agents according to (1) or (2), wherein said N-acylated hydroxyproline derivatives are N-acetylated hydroxyproline derivatives or N-propionated hydroxyproline derivatives.
(4) The skin aging inhibitors and/or skin quality-improving agents according to any one of (1) to (3), wherein said hydroxyproline is selected from the group consisting of cis-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, cis-3-hydroxy-L-proline, cis-3-hydroxy-D-proline, trans-4-hydroxy-L-proline, trans-4-hydroxy-D-proline, trans-3-hydroxy-L-proline and trans-3-hydroxy-D-proline.
(5) The skin aging inhibitors and/or skin quality-improving agents according to any one of (1) to (4), wherein said hydroxyproline is produced by using a microorganism.
(6) The skin aging inhibitors and/or skin quality-improving agents according to (5), wherein proline 3-hydroxylase or proline 4-hydroxylase gene derived from a microorganism belonging to a genus selected from the group consisting of the generaAmycolatopsis, Dactylosporangium and Streptomyces is introduced into the microorganism.
(7) The skin aging inhibitors and/or skin quality-improving agents according to any one of (1) to (6), wherein said skin aging inhibitors and/or skin quality-improving agents are agents for promoting the proliferation of epidermal cells.
(8) The skin aging inhibitors and/or skin quality-improving agents according to any one of (1) to (6), wherein said skin aging inhibitors and/or skin quality-improving agents are agents for promoting the collagen synthesis of fibroblast.
(9) The skin aging inhibitors and/or skin quality-improving agents according to any one of (1) to (6), wherein said skin aging inhibitors and/or skin quality-improving agents are agents for improving the moisture retention function of epidermis.
(10) The skin aging inhibitors and/or skin quality-improving agents according to any one of (1) to (6), wherein said skin aging inhibitors and/or skin improving agents are agents for inhibiting and/or improving the wrinkle formation.
(11) The skin aging inhibitors and/or skin quality-improving agents according to any one of (1) to (10), wherein said skin is human skin.
(12) Cosmetic
Kamimura Ayako
Kobayashi Asako
Makimoto Yutaka
Sakakibara Toshihiro
Tajima Minako
Fitzpatrick ,Cella, Harper & Scinto
Kyowa Hakko Kogyo Co. Ltd.
Patterson Jr. Charles L.
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