Percutaneous administration preparations

Details Percutaneous administration preparations Percutaneous administration preparations

2001-10-25

2004-12-07

Azpuru, Carlos A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

C514S772300

Reexamination Certificate

active

06827944

ABSTRACT:

TECHNICAL FIELD
The present invention relates to a composition for percutaneous administration which is particularly useful for percutaneous administration of a water soluble active ingredient and is excellent in feeling upon use and convenient to use.
BACKGROUND ART
Known methods for administration of pharmacological active ingredients are percutaneous administration, oral administration, injection, and the like. In particular, percutaneous administration is commonly used to decrease degradation in digestive tracts or first pass effect compared with oral administration, to reduce pain or burden given to patients compared with injection, and to continue administration for long hours. However, the skin essentially serves as a barrier for preventing invasion of foreign substances from the outside or evaporation of moisture in the body. The permeability of skin is lower than that of the general biomembrane.
A cataplasm using a hydrous gel preparation is one example of a means permitting efficient percutaneous absorption of pharmacological active ingredients. Accelerating efficacy of percutaneous absorption of the cataplasm is based on hydration and expansion of most outer layer of the epidermis, which is the horny cell layer of the skin and serves as a barrier of percutaneous absorption.
Since a cataplasm is formed by applying a hydrous gel containing an active ingredient to a backing material such as nonwoven cloth, it has suitable thickness and therefore lacks flexibility. In addition, adhesion of the hydrous gel layer to the skin is insufficient. As a result, it causes uncomfortable feeling during use, easily peels off from the skin by failing to move, and fails to provide sufficient acceleration of percutaneous absorption.
A composition for percutaneous administration containing a substance softening or hydrating the keratin layer such as urea or polyol has been proposed. However, efficacy of percutaneous absorption of active ingredients is still insufficient.
An object of the present invention is therefore to provide a composition for percutaneous administration which exerts an excellent percutaneous absorption performance of an active ingredient, has excellent feeling and is convenient to use.
DISCLOSURE OF THE INVENTION
The inventors have found that a composition for percutaneous administration comprising a polymer mixture which forms a surface-segregated film and an active ingredient provides efficient percutaneous absorption of an active ingredient when applied to the skin, has excellent feeling and is convenient to use.
The present invention therefore provides a composition for percutaneous administration comprising the following components (A) and (B):
(A) a polymer mixture which forms a surface-segregated film; and
(B) an active ingredient.


REFERENCES:
patent: 5240995 (1993-08-01), Gyory et al.
patent: 0 326 278 (1989-08-01), None
patent: 0 524 612 (1993-01-01), None
patent: 0 640 643 (1995-03-01), None
patent: 0 863 172 (1998-09-01), None
patent: 30-99 (1955-01-01), None
patent: 60-123416 (1985-05-01), None
patent: 60-123416 (1985-07-01), None
patent: 62-240612 (1987-10-01), None
patent: 2-258718 (1990-10-01), None
patent: 3-112926 (1991-05-01), None
patent: 3-11530 (1991-11-01), None
patent: 3-111530 (1991-11-01), None
patent: 5-112423 (1993-05-01), None
patent: 6-507422 (1994-08-01), None
patent: 9-291020 (1997-11-01), None
patent: 10-226637 (1998-08-01), None
patent: 2000-44476 (2000-02-01), None

Affiliated with

Also associated with

Rating

Percutaneous administration preparations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Percutaneous administration preparations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Percutaneous administration preparations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3326558