Quinolonecarboxamide compounds, their preparation and use as ant

Details Quinolonecarboxamide compounds, their preparation and use as ant Quinolonecarboxamide compounds, their preparation and use as ant

1989-06-23

1990-09-25

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514312, 544128, 546153, 546155, 546156, C07D215233, C07D26530, A61K 3147, A61K 31535

Patent

active

049593633

ABSTRACT:
Compounds of the formula ##STR1## where R is hydrogen, hydroxy, amino or lwer-alkyl; R.sup.1 is lower-alkyl, lower-alkenyl, cycloalkyl, pyridinyl, phenyl or substituted phenyl; R.sup.2 is hydrogen, amino or hydroxy; R.sup.6 is hydrogen or fluoro; and R.sup.7 is phenyl, pyridinyl or selected other heterocycles, have antiviral acitivity against herpes virus.
The compounds are prepared from the corresponding carboxylic acids or ester, or by a tin-coupling reaction on the corresponding 7-halo compounds.

REFERENCES:
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patent: 3753993 (1973-08-01), Lesher et al.
patent: 3966743 (1976-06-01), Berger et al.
patent: 4499091 (1985-02-01), Wentland et al.
patent: 4636506 (1987-01-01), Gilligan et al.
patent: 4730000 (1988-03-01), Chu
patent: 4786644 (1988-11-01), Glamkowski et al.
Angelino et al., J. Heterocyclic Chem., 21, 107-112, (1984).

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