Synthetic polystyrene resin and its use in solid phase peptide s

Details Synthetic polystyrene resin and its use in solid phase peptide s Synthetic polystyrene resin and its use in solid phase peptide s

1989-05-17

1991-04-02

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530333, 530334, C08F28300, C08G 6348, C08G 6391

Patent

active

050047817

ABSTRACT:
A synthetic resin based on a polystyrene that can be used as a support for solid phase peptide synthesis and that has been cross-linked with from 0 to 5 mol % of divinyl benzene, characterized in that it has been substituted at benzene rings of its skeletal structure by groups of the formula ##STR1## in which X represents --O-- or --NH-- and R represents C.sub.1 -C.sub.4 -alkyl, as a support renders possible the solid phase synthesis of peptides and peptide amides that are, if desired, protected at the N-terminal and/or at other functional groups. The resin is manufactured by reaction of a customary chloromethylated polystyrene resin with an alkali metal salt of the corresponding 4-hydroxybenzophenone and subsequent reduction of the carbonyl group and, optionally, amination.

REFERENCES:
patent: 4301045 (1981-11-01), Kaiser et al.
patent: 4507230 (1985-03-01), Tam et al.
patent: 4569967 (1986-02-01), Kornreich et al.
patent: 4623484 (1986-11-01), Carpino et al.

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