Nucleic acids encoding hencatoporetic stem cell receptor flk-2

Details Nucleic acids encoding hencatoporetic stem cell receptor flk-2 Nucleic acids encoding hencatoporetic stem cell receptor flk-2

1991-12-24

1993-02-09

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4353201, 530350, 530403, C07H 2100

Patent

active

051854384

ABSTRACT:
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1 (flk-2) and FIG. 2 (flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1 (flk-2) and FIG. 2 (flk-1); ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.

REFERENCES:
Lemischka et al., Cell 45, 917-927 (1986).
Flanagan and Leder, Cell 63, 185-194 (1990).
Jordan et al., Cell 61, 953-963 (1990).
Spangrude et al., Science 241, 58-62 (1988).
Wilks, Proc. Natl. Acad. Sci. USA 86, 1603-1607.
Hanks, et al., Science 241, 42-52 (1988).
Rosnet, Genomics 9, 380-385 (1991).
Rosnet et al., Oncogene 6, 1641-1650.

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