Pro-liposome compositions

Details Pro-liposome compositions Pro-liposome compositions

1988-03-21

1991-04-02

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 3722

Patent

active

050046110

ABSTRACT:
Pro-liposome compositions comprise membrane lipids such as lecithin or distearyl dimethylammonium chloride, water-miscible solvents such as ethanol, optionally a minor proportion of water, and optionally fatty acid esters and drugs. On addition to excess water they spontaneously form dispersions of liposomes having high void volumes and high drug entrapment ratios.
Aerosol compositions are presented in a volatile liquid propellant. On being sprayed they form an aerosol of droplets which, on contact with aqueous media, spontaneously form liposome dispersions.

REFERENCES:
patent: 4590060 (1986-05-01), Ehrenfeld
Chemical Abstracts 105: 12154c (1986).
Chemical Abstracts 103: 27287f (1985).
Chemical Abstracts 103: 156792r (1985), Hauser et al.

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