Triazolobenzodiazepines

Details Triazolobenzodiazepines Triazolobenzodiazepines

1991-05-14

1993-02-09

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3155

Patent

active

051853310

ABSTRACT:
Pharmaceutical compositions containing Triazolobenzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.

REFERENCES:
patent: 4663321 (1987-05-01), Bock et al.
patent: 4820834 (1989-04-01), Evan et al.
patent: 07/852478 (1992-03-01), Freidinger et al.
Bradwejn, et al., Enhanced Sensitivity to Cholecystokinin Tetrapeptide in Panic Disorder, Soc. Neurosci. Abstr. 14(1), p. 291, (1988).
de Montigny, Cholecystokinin Tetrapeptide Induces Panic Attacks in Healthy Volunteers, Soc. Neurosci. Abstr. 14(1), p. 291, (1988).
Bradwejn, et al., Benzodiazepines Antagonize Cholecystokinin-Induced Activation of Rat, Hippocampal, Nature 312, p. 22, (1984).
de Montigny, Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers, Arch. Gen. Psychiatry, 46, (1989).
Dourish, et al., Morphine Induced Analgesia in the Rat Paw Pressure Test is Blocked by CCK and Enhanced by the CCK Antagonist MK-329, Eur. Jour. Pharm. 147, No. 3, pp. 469-472, (1988).
Bouthillier, et al., Long-term Benzodiazepine Treatment Reduces Neuronal Responsiveness to Cholecystokinin: an Electrophysiological Study in the Rat, Eur. Jour. Pharm. 151, No. 1, pp. 135-138, (1988).

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