Method of producing (R)-tertiary leucine

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

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435106, C12P 1304, C12P 1306

Patent

active

057078378

ABSTRACT:
A method is disclosed by which N-carbamoyl-(R)-tert.-leucine is obtained from tert-butyl hydantoin by means of an (R)-specific hydantoinase, in which N-carbamoyl-(R)-tert.-leucine is converted by reaction with nitrite or an (R)-carbamoylase to (R)-tert-leucine.

REFERENCES:
patent: 4744990 (1988-05-01), Bragdon et al.
patent: 4871552 (1989-10-01), Bragdon et al.
patent: 5516660 (1996-05-01), Wagner et al.
Bommarius, et al., Tetrahedron: Asymmetry, (1995) "Synthesis and Use of Enantiomerically Pure Tert-Leucine", pp. 2853-2888.

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