Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2001-04-03
2004-03-09
Fonda, Kathleen K. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S002600, C514S062000, C536S053000, C530S350000, C623S016110
Reexamination Certificate
active
06703377
ABSTRACT:
BACKGROUND OF THE INVENTION
Hyaluronic acid is a naturally-occurring polysaccharide containing alternating N-acetyl-D-glucosamine and D-glucuronic acid monosaccharide units linked with beta 1-4 bonds and the disaccharide units linked with beta 1-3 glycoside bonds. It occurs usually as the sodium salt and has a molecular weight range of about 50,000 to 8×10
6
.
SUMMARY OF THE INVENTION
The present invention provides a bone growth-promoting composition comprising hyaluronic acid and a growth factor such that the composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote bone growth.
Compositions comprising hyaluronic acid and a growth factor are provided which have the requisite viscosity and biodegradability.
As used herein, the term hyaluronic acid, abbreviated as HA, means hyaluronic acid and its salts such as the sodium, potassium, magnesium, calcium, and the like, salts.
By growth factors, it is meant those factors, proteinaceous or otherwise, which are found to play a role in the induction or conduction of growth of bone, ligaments, cartilage or other tissues associated with bone or joints.
In particular these growth factors include bFGF, aFGF, EGF (epidermal growth factor), PDGF (platelet-derived growth factor), IGF (insulin-like growth factor), TGF-&bgr; I through III, including the TGF-&bgr; superfamily (BMP-1 through 12, GDF 1 through 12, dpp, 60A, BIP, OF).
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Beyer Weaver & Thomas
DePuy Acromed, Inc.
Fonda Kathleen K.
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