Method for producing oxime ethers

Details Method for producing oxime ethers Method for producing oxime ethers

2002-10-10

2004-01-20

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

06680410

ABSTRACT:

The present invention relates to a process for preparing oxime ethers of the formula I
in which the substituents R
1
and R
2
can be identical or different and can each be cyano, C
1
-C
4
-alkyl, C
1
-C
4
-halogenalkyl, C
3
-C
6
-cycloalkyl, phenyl and naphthyl, and R
3
can be C
1
-C
4
-alkyl, by alkylation of oximes of the formula II
under basic conditions with an alkylating agent from the group of alkyl halides, dialkyl sulfates and dialkyl carbonates, wherein the reaction is carried out in a mixture consisting of
5 to 25% by weight of polar aprotic solvents selected from the group of nitrites, N-alkylpyrrolidones, cyclic urea derivatives, dimethylformamide and dimethylacetamide,
55 to 95% by weight of nonpolar solvents selected from the group of aliphatic hydrocarbons, aromatic hydrocarbons, alkyl alkylcarboxylates and ethers, and
0 to 25% by weight of water, the contents thereof totaling 100%.
Processes for alkylating activated oximes are known from the prior art.
Bull. Acad. Sci. USSR, Div. Chem. Sci. (Engl. Transl.), EN, vol. 28, pp. 121-128 (1979) describes oxime alkylation reactions through diazoalkanes, alkyl halides and dialkyl sulfates; the competition between oxygen and nitrogen alkylation is investigated in particular. Preparation of the O-alkyl ethers of &agr;,&agr;′-biscarbonyloximes in moderate yields in acetone, ethanol, water or diethyl ether is described. To favor O-alkylation it is recommended that the highest possible temperatures be used because the nitrones are thermally unstable, or that the alkylating reagents are as bulky as possible.
Ind. J. Chem., vol 30B, pp. 749-753 (1991) describes the methylation of oximes of the formula II in which R
1
and R
2
are methyl or phenyl. Reaction with methyl iodide in the presence of anhydrous K
2
CO
3
in acetone results in the O-methyl ethers in yields of 65 or 67%.
WO-A 00/18726 describes the alkylation of oximes of the formula II in various solvents. The reaction can also take place in mixtures of these solvents.
When such syntheses are carried out on an industrial scale there are technical advantages in using water-containing solvent mixtures. A water content does, however, normally lead to losses of yield.
It is an object of the present invention to provide an economic and industrially applicable process for preparing oxime O-alkyl ethers of the formula I which has high selectivity and yields even in water-containing solvent mixtures and is simple to carry out.
We have found that this object is achieved by a process for preparing oxime ethers of the formula I
in which the substituents R
1
and R
2
can be identical or different and can each be cyano, C
1
-C
4
-alkyl, C
1
-C
4
-haloalkyl, C
3
-C
6
-cycloalkyl, phenyl and naphthyl, and R
3
can be C
1
-C
4
-alkyl, by alkylation of oximes of the formula II
under basic conditions with an alkylating agent from the group of alkyl halides, dialkyl sulfates and dialkyl carbonates, wherein the reaction is carried out in a mixture consisting of
5 to 25% by weight of polar aprotic solvents selected from the group of nitrites, N-alkylpyrrolidones, cyclic urea derivatives, dimethylformamide and dimethylacetamide,
55 to 95% by weight of nonpolar solvents selected from the group of aliphatic hydrocarbons, aromatic hydrocarbons, alkyl alkylcarboxylates and ethers, and
where appropriate up to 25% by weight of water.
In the process of the invention, contrary to the teaching of the prior art, at moderate temperatures surprisingly no nitrone formation is observed, and the O-alkyl ethers are obtained in good to very good yields, despite the use of sterically undemanding alkylating agents and substrates.
Suitable bases are in general salt-like compounds such as alkali metal and alkaline earth metal carbonates such as sodium carbonate, potassium carbonate and magnesium carbonate, and alkali metal bicarbonates such as sodium bicarbonate, also alkali metal acetates such as sodium acetate. Potassium carbonate is particularly preferred.
The base is generally used in the equimolar quantity or in excess; an excess of about 10 to 30% has proven advantageous in many cases. The base can be employed in solid form or as solution, in particular as aqueous solution. For practical reasons, it is preferred to use at least 10% by weight and up to saturated aqueous solutions.
Suitable solvents are aliphatic hydrocarbons such as pentane, hexane, cyclohexane and petroleum ether, aromatic hydrocarbons such as toluene, o-, m- and p-xylene, halogenated hydrocarbons such as methylene chloride, chloroform and chlorobenzene, ethers such as diethyl ether, diisopropyl ether, tert-butyl methyl ether, dioxane, anisole and tetrahydrofuran, and N-methylpyrrolidone, N-octylpyrrolidone, cyclic urea derivatives such as dimethylpropyleneurea, dimethyl sulfoxide, dimethylformamide and dimethylacetamide, particularly preferably dimethylformamide and dimethylacetamide, aromatic hydrocarbons such as toluene and ethers such as tert-butyl methyl ether.
The reaction is carried out in a solvent mixture which consists of 5 to 25% by weight, preferably 10 to 20% by weight, of the aforementioned polar aprotic solvents, up to 25% by weight of water and at least 5% by weight, preferably 55 to 95% by weight and particularly preferably 60 to 90% by weight, in particular 60 to 80% by weight, of the aforementioned nonpolar solvents.
It is preferred to carry out the process in water-containing solvent mixtures for technical reasons.
Suitable alkylating agents are alkyl halides, dialkyl sulfates and dialkyl carbonates. Dialkyl sulfates are preferred for economic reasons.
The alkylating agent is generally used in the equimolar quantity or in excess; an excess of about 5 to 15% by weight has proven advantageous in many cases.
For safety reasons, when alkyl halides and dialkyl sulfates are used it is normal to destroy excess alkylating agent after the reaction, and ammonia or amines such as, for example, diethylamine are mostly used for this.
In a preferred embodiment of the process, methylating agents are used.
The reaction is normally carried out at temperatures from 0 to 100° C., preferably at 0 to 50° C. and very particularly preferably at 10 to 25° C. The reaction temperature is normally set appropriate for the thermal stability of the oxime.
The sequence of addition of the reactants is not critical. In a preferred embodiment of the process, the base, as solid or as aqueous solution, is introduced into the solvent, and the oxime and the alkylating agent are added simultaneously and in equimolar quantity to the solvent mixture which contains water where appropriate. In another preferred embodiment, the oxime is added to a part or all of the alkylating agent.
The process of the invention is not restricted to compounds with particular substituents as long as the substituents are inert under the reaction conditions. Aliphatic radicals may be straight-chain or branched. The chain length of the substituents is immaterial for the process of the invention, but for technical reasons radicals with no more than 4 C atoms will normally be chosen.
The process is very particularly preferably used to prepare pentane-2,3,4-trione 3-O-methyloxime.
Alkyl is generally C
1
-C
10
-alkyl, in particular C
1
-C
4
-alkyl, which also applies to haloalkyl; cycloalkyl radicals have three to six ring members.
The substituents R
1
and R
2
may carry other radicals which are inert under the reaction conditions, the following being mentioned by way of example: halogen, cyano, SO
3
H, COOH, COOR
4
, C
1
-C
10
-alkyl, C
2
-C
8
-alkenyl, C
2
-C
8
-alkynyl, phenyl or hetaryl; R
4
is C
1
-C
10
-alkyl.
Hetaryl is, for example, furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, imidazolyl, pyridyl, pyridazinyl, pyrimidinyl or triazinyl;
Halogen is chlorine, fluorine, bromine or iodine.
Alkenyl and alkynyl radicals have two to eight, in particular three to six, C atoms.
The oxime O-alkyl ethers obtainable by the process of the invention are suitable as intermediates for preparing dyes or active ingredients in the drugs or crop protecti

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