Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2001-01-16
2003-11-04
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C424S439000, C424S728000, C424S729000, C424S739000, C424S741000, C424S756000, C514S002600
Reexamination Certificate
active
06641846
ABSTRACT:
FIELD OF THE INVENTION
This invention is related to a pharmaceutical composition with its main effect against Type I Allergy, especially to one medicament with anti-allergic effect, which can also be used as an immune regulator.
This invention is also related to a method of a pharmaceutical composition with its main effect against Type I Allergy.
BACKGROUND OF THE INVENTION
Allergic diseases are common ones that harm human health seriously. Especially with the pollution of living environment of human beings and the changed dietary structures, patients suffering from allergic diseases are increasing rapidly. In an article in the American newspaper, “Medical Forum”, of Jan. 12, 2000, it was reported that “there are about 38% of Americans who suffer from some types of allergic diseases”. Additionally, according to some related statistical materials, in the world, there are about 700-800 millions of people who suffer from allergic diseases, among whom the patients suffering from Type I Allergy amount to quite a great proportion. Type I Allergy is a reaction that occurs rapidly when human makes contact again with its allergic antigen. In clinical cases, it is common that the allergic diseases are allergic asthma, allergic rhinitis, allergic dermatitis, allergic gastroenteritis, etc. Serious allergic diseases can even cause patients to go into shock. The pathogenesis of Type I Allergy is that the antigen-antibody reaction occurs on the surface of mastocytes. Said mastocytes are following to be damaged and cAMP in cell plasma is reduced with increased cGMP and penetrability of cell membrane is changed, so that it rapidly releases allergic active mediums, such as histamine, 5-hydroxytryptamine (5-HT), bradykinin or slowly reactive materials and the like.
In the modern medical researches, it is proven that regulation of human cAMP, cGMP and IgE can inhibit and take precautions against Type I Allergy effectively to prevent from releasing allergic mediums and reducing the reaction from local inflammation reaction of target cells. But in the Chinese traditional medicine theory, it is thought that it occurs due to general debility in three internal organs of lung, spleen and kidney, which leads to pathological changes such as deficiency and lack of vital energy, turbid asthma, etc. And allergic diseases would occur easily under external unhealthy conditions.
At present, anti-histamine and anti-allergic inhibitors as medicament are taken to cure allergy. But the effects of these medicines known in the arts only remain for a short time with a lot of side effect to a different degree, so that people cannot take them for a long time. People can only take said medicament in allergic occurrence to relieve the symptoms of allergic reactions locally. But it is difficult to improve allergic constitution, inhibit and prevent from allergic reactions through regulating human immune functions. With Chinese medicines, allergic diseases can be cured according to their symptoms by means of counteraction and harmonization and building up human resistance to diseases. Although Chinese Medicaments have good immune regulative effects, doctors of traditional Chinese medicine have not taken allergy as one independent course of study and made researches on it. Up to now, they have not combined the research results in incidence pathogenesis of allergy, which are obtained in modern medicines, with traditional herb prescriptions that can cure allergic diseases. The traditional medical doctors have not begun correcting allergic constitution to inhibit and prevent from allergic diseases by means of effective regulation of human cAMP/cGMP and IgE.
In order to overcome deficiency of the prior arts, the object of this invention is to provide one pharmaceutical composition with its main effects against Type I Allergy, especially herb medicament.
The present pharmaceutical composition is prepared with purely natural plants or herbs as its raw materials without any side effects and can inhibit and prevent Type I Allergy by means of regulation of human cAMP/cGMP. It can be used as an anti-allergic immune regulator that can be taken for a long time.
Another object of this invention is to provide a preparation method of the above-mentioned pharmaceutical composition with its main effects against Type I Allergy.
SUMMARY OF THE INVENTION
According to the present invention, the said medicament is prepared with purely natural herbs as its raw materials that can be taken as medicaments or as food. Such medicament has no side effects and can regulate immune functions of human body, harmonize allergic constitution of patients, inhibit and prevent human Allergy.
The embodiment of this invented medicament is based on the knowledge and pathogenesis of incidence of allergic diseases in traditional Chinese medicine in combination of the research achievements in the modern medicine and pharmacology. By use of pharmacologically acceptable active herb with function of immune regulation, the anti-allergic effects of the traditional Chinese herb medicines are strengthened and optimized, especially, this immune regulator not only can be taken for a long time to prevent incidence of allergic diseases through correcting allergic constitution of patient, but also can cure symptoms of allergic diseases effectively by their incidence.
In order to achieve the object of this invention, the following technical embodiments are taken for the present invention:
As mentioned above, this invention refers especially to a pharmaceutical composition with its main effects against Type I Allergy. In the invention, common jujube fruit (
Fructus Jujubae
) is used in fresh or dried one. It is a fruit of
Ziziphus jujuba
Mill. Membranous milk vetch root (
Radix Astragali
), a root of herb called
Astragalus membranaceus
(Fisch.) Bge. or
Astragalus membranaceus
(Fisch.) Bge. Var. mongholicus Bge. Hsiao and ural Licorice root (
Radix glycyrrhizae
), a root of herb called
Glycyrrhiza uralensis
Fisch., Cassiabarktree branchlet (
Ramulus cinnamomi
), Ginger and Green tea are also used as raw material for the herb medicament.
A herb medicament or pharmaceutical composition is prepared as the raw materials in accordance with the following weight ratio:
Fructus Jujubae
30 ~ 60 parts
Radix Astragali
12 ~ 55 parts
Radix glycyrrhizae
8 ~ 15 parts
Ramulus cinnamomi
6 ~ 12 parts
Ginger
6 ~ 12 parts
Green tea
4 ~ 8 parts
The preferred prescription of this pharmaceutical composition is prepared with the raw materials in accordance with the following weight ratio:
Fructus Jujubae
35 ~ 55 parts
Radix Astragali
15 ~ 50 parts
Radix glycyrrhizae
8 ~ 12 parts
Ramulus cinnamomi
6 ~ 10 parts
Ginger
6 ~ 10 parts
Green tea
5 ~ 7 parts
The most preferred prescription of this pharmaceutical composition is prepared as raw materials in accordance with the following weight ratio:
Fructus Jujubae
50 parts
Radix Astragali
30 parts
Radix glycyrrhizae
10 parts
Ramulus cinnamomi
8 parts
Ginger
8 parts
Green tea
6 parts
In the above-mentioned pharmaceutical composition with its main effects against Type I Allergy, optionally, common peony root, the root of herbaceous peony (
Radix Paeoniae Alba
)(10 20 parts) and/or Baikal skullcap root (
Radix scutellariae
) (10-20 parts) can also be added to strengthen its anti-allergic effects further.
The pharmaceutical composition mentioned in this invention contains pharmaceutically acceptable additives. And the mentioned medicament can be made to form any type of drug described in pharmacy, preferably drug in form of powder or tablet.
This invention is also related to an extract of the pharmaceutical composition with its main effects against Type I Allergy. The said extract is obtained with the following steps:
1. 30~60 weight parts of
Fructus Jujubae
are putted into a warm alcohol solution and keeping its pH value between 3.6~3.8. After it is extracted and filtered, the extract solution is obtained. Then, the said extract solution is absorbed several times with macro porous resin fo
Fu Yanling
Zhang Zuoguang
Flood Michele C.
Morrison & Foerster / LLP
Tate Christopher R.
Tianjin Yanling Health Food Co.
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