Estrenes for inducing hypothalamic effects

Details Estrenes for inducing hypothalamic effects Estrenes for inducing hypothalamic effects

1997-06-04

1999-08-17

Cook, Rebecca

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552646, C07J 100

Patent

active

059395702

ABSTRACT:
The invention relates to estrene steroids, which bind to neuroepithelial receptors. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.

REFERENCES:
patent: 3231586 (1966-01-01), Greenspan
patent: 3264327 (1966-08-01), Knox
patent: 3329579 (1967-07-01), Sax et al.
patent: 3347878 (1967-10-01), Boswell et al.
patent: 3681490 (1972-08-01), Melrose et al.
patent: 3960841 (1976-06-01), Engel et al.
patent: 4071624 (1978-01-01), Grunwell et al.
patent: 4071625 (1978-01-01), Grunwell et al.
patent: 4075233 (1978-02-01), Marx et al.
patent: 4087524 (1978-05-01), Grunwell et al.
patent: 4117234 (1978-09-01), Johnson et al.
patent: 4139617 (1979-02-01), Grunwell et al.
patent: 4239681 (1980-12-01), Grunwell et al.
patent: 4330538 (1982-05-01), Itil et al.
patent: 4340602 (1982-07-01), Brooks et al.
patent: 4425339 (1984-01-01), Pitchford
patent: 4835147 (1989-05-01), Roberts
patent: 4863911 (1989-09-01), Anderson et al.
patent: 5155045 (1992-10-01), Cutler et al.
patent: 5272134 (1993-12-01), Berliner
Hussain et al., "Administering natural female sex hormones," Pharmaceuticals, vol. 96, p. 421, 1982, CA 96: 187314.
Monti-Bloch et al., "Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium," J.Steroid biochem, and Molec. Biol., vol. 39, No. 4B, pp. 573-582, 1991.
Bird et al., "Estimation of the odorous steroid, 5-alpha-androst-16-en-3-one, in human saliva," CA: 99(1):64581s, 1983.
Chakravarti et al., Relation between plasma hormone profiles, symptoms, and response to estrogen treatment in women approaching the menopause, CA 91-124649f, 1979.
Lauber et al., "Estradiol induction of proenkephalin messenger RNA in hypothalamus: dose-response and relation to reproductive behavior in the female rate," CA 113: 165668p. 1990.
Perry et al., "Pig courtship behavior: pheromonal property of androstene steroids in male submaxillary secretion," CA 94: 45007q, 1980.
Thomson et al., "Sexual behavior, seminal pH and accessory sex glad weights in geldings administered testosterone and (or) estradiol-17.beta," CA 94:77415n, 1980.
Arunachalem, T. et al., "Iodoestrogens, Syntheses, and Interaction with Uterine Receptors," the Journal of Biological Chemistry, vol. 254, No. 13, pp. 5900-5905, Jul. 10, 1979.
Garcia-Velasco et al., Aesth. Plast. Surg. 19:451-454 (1995).
Axel, Scientific American, Oct. 1995 pp. 154-159.
Pindur, Ulf, et al., Chemical Abstract No. 187856, vol. 122, "Proton acid-catalyzed transformations of estrogen derivatives: new results and some mechanistic aspects of the Kober color reaction," Arch. Pharm. (1994) 327(10), pp. 637-642.
Toth, Gabor, et al., Chemical Abstract No. 191221, vol. 88, "Chromogen reaction of 4-en-3-one steroids with an additional keto group in 17- or 20-position," Collect. Czech. Chem. Commun. (1978) 43(1), pp. 165-177.
Agosta, W.C., "Chemical Communication (The Language of Pheromones)," Scientific American Library, New York, Chapter 6, pp. 130-140, 1992.
Beauchamp et al., "The pheromone concept in mammalian chemical communications: A Critique," Mammalian Offaction Reproductive Processes, and Behavior, Doty, RLL, Ed., Academic Press, New York, pp. 143-160, 1976.
Brooksbank et al., "Fate of Androsta-4, 15-dien-3-one and the origin of 3a-hydroxy-5a-androst-16-ene in man," J.Endocr., vol. 52, pp. 239-251, 1972.
Claus et al., "The boar-pheromone steroid indentified in vegetables," Experimentia, vol. 25, pp. 1674-1675, 1979.
Claus et al., "Occurrence of 5a-androst-16-en-3-one, a boar pheromone, in main and its relationship to testosterone," J. Endocr., vol. 68, pp. 483-484, 1976 (abstract).
Foreman et al., "Preclinical studies on quinelorane, a potent and highly selective Dx-Dopamineric agonist," J. Pharmacology and Experimental Therapeutics, vol. 250, No. 1, pp. 227-235, 1989.
Garcia Velasco et al., "The Incidence of the vomeronasal organ in 1000 human subjects and its possible clinical significance," J. Steroid Biochem. and Molec. Biol., vol. 39, No. 4B, pp. 561-563, 1991.
Gower et al., "The significance of odorous steroids in axillary odour," Perfumery: The Psychology and Biology of Fragrance, Van Toller et al., Eds., Chapman and Hall, London, pp. 47-75, 1988.
Johnson et al., "clinical and histological evidence for the presence of the vomeronasal (Jacobson's) organ in adult hunans," J. Otolaryngology, vol. 14, No. 2, pp. 71-79, 1985.
Kirk-Smith et al., "Human social attitudes affected by androstenol," Research Communications in Psychology, Psychiatry, and Behavior, vol. 3, No. 4, pp. 379-384, 1978.
Kwan et al., "15-androstenes, putative pheromones in human semen," Med.Sci.Res., vol. 15, pp. 1443-1444, 1987.
Melrose et al., "Androgen-steroids associated with boar odour as an aid to the detection of oestrus in pig artificial insemination," Br.Vet.J., vol. 127, pp. 497-502, 1971.
Moran et al., "The vomeronasal (Jacobson's) organ in man: Ultrastructure and frequency of occurrence," J. Steroid Biochem. and Molec. Biol, vol. 29, No. 4B, pp. 545-522, 1991.
Muller-Schwarze et al., Eds., "Chemical Signals (Vertebrates and Aquatic Invertebrates)," Plenum Press, New York 1980.
Parott, R.F., "Homotypical sexual behavior in gonadectomized female and male rats treated with 5a-19-Hydroxytestosterone: Comparison with related androgens," Hormones & Behavior, vol. 7, pp. 207-215, 1976.
Phoenix, C.H., "Sexual behavior of castrated male rhesus monkeys treated with 19-Hydroxytestosterone," Physiology & Behavior, vol. 8 pp. 356-362 1977.
Reed et al., "Androgen steroids as an aid to the delection of oestrus in pig artificial insemination," Br. Vet. J. vol. 130, pp. 61-65, 1974.
Stensaas et al., "Ultrastructure of the human vomeronasal organ," J. Steroid Biochem, and Molec.Biol., vol. 39, No. 4B, pp. 553-560, 1991.
Michael et al., "Pheromones in the communication of sexual status in primates," Nature, vol. 218, pp. 746-749, 1968.
Physicians Desk Reference, 31 st Ed., pp. 598-599, Premarin, 1977.
Te Merck Index, 11th Ed., "Estrone" No. 3660, 1989.
Phoenix, C.H., "Induction of sexual behavior in ovariectomized shesus females with 19-Hydroxytestosterone," Hormones & Behavior, vol. 8, pp. 356-362, 1977.
"Olfaction in Human with special reference to odorous 16-androstenes: their occurance, perception and possible social, psychological and sexual impact", Chemical Abstracts, vol. 118, No. 25, 1992, see abstract No. 247775p, J. Endocrin., 137(2), 167-168.
Ohloff et al., "Structural and configurational dependence of the sensory process in steroids", Helv Chim. Acta, vol. 66, pp. 192-217, (1983).
Phoenix, C.H., "Sexual behavior of castrated male rhesus monkeys treated with 19-Hydroxytestosterone", Physiology & Behavior, vol. 16, pp. 305-310, (1976).
The Merck Index, 11th Ed., "Estrone", No. 3660, (1989).
CA 68: 3116.
CA 97: 168926.
CA 112: 173065.

Affiliated with

Also associated with

Rating

Estrenes for inducing hypothalamic effects does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Estrenes for inducing hypothalamic effects, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Estrenes for inducing hypothalamic effects will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-316020