Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-11-17
1999-08-17
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303873, 5303881, 53038826, 53038885, C07K 1600, C12P 2108
Patent
active
059395303
ABSTRACT:
Antigen binding polypeptides that specifically bind human cytochrome P450 3A3, 3A4, and 3A5 and that specifically inhibit the enzyme activity of human cytochrome P450 3A3, 3A4, and 3A5 are described. Antigen binding polypeptides that specifically bind to human cytochrome P450 3A3 and 3A4 are also described. Antigen binding polypeptides which specifically bind to human cytochrome P450 2E1 and which specifically inhibit the enzyme activity of human cytochrome P450 2E1 are described. Antigen binding polypeptides which specifically bind to human cytochrome P450 2E1 are also described. Methods of determining the contribution of human cytochrome P450s to the metabolism of compounds, using the antigen binding polypeptides of the invention, are also described.
REFERENCES:
patent: 4946778 (1990-08-01), Ladner et al.
Kerr et al (Pharm Res, 1991, 8 No. 10 Suppl. S239).
Christians et al (Ther. Drug. Monit, 1993, 15#2, 145).
Ohmori et a (Biol. Pharm. Bull, 1993, 16:571-575).
Yon et al (Anesthesiology, 1992, 77:467-474).
Patten et al (Chem. Res. Toxicol, 1993, 6:511-518.
Gillam et al (Arch. Biochem & Biophys, 1994, 312;59-66).
Aoyama et al, Endocrinology,126: 3101,-3106(1990).
Harlow & Lane, Antibodies, Cold Spring Harbor Laboratory 1988, p. 141.
Francois Berthou et al., "Involvement of Cytochrome P450 3A Enzyme Family in the Major Metabolic Pathways of Toremifene in Human Liver Microsomes," Biochemical Pharmacology, 1994, vol. 47, No. 10, London, GB, pp. 1883-1895.
Thomas K. H. Chang et al., "Differential Activation of Cyclophosphamide and Ifosphamide by Cytochromes P-450 2B and 3A in Human Liver Microsomes," Cancer Research, Dec. 1, 1993, vol. 53, No. 23, CNREA 8, Baltimore, MD, USA, pp. 5629-5637.
Harry V. Gelboin et al., "Inhibitory and Non-Inhibitory Monoclonal Antibodies to Human Cytochrome P450 3A3/4," Biochemical Pharmacology, vol. 50, No. 11, 1995, London, GB, pp. 1841-1850.
Harry V. Gelboin et al., "Inhibitory and Non-Inhibitory Monoclonal Antibodies to Human Cytochrome P450 2E1," Chemical Research in Toxicology, Sep. 1996, vol. 9, No. 6, CRTOEC 9 (6) 917-1056 (1196), London, GB, pp. 1023-1030.
James W. Harris et al., "Metabolism of Taxol by Human Hepatic Microsomes and Liver Slices: Participation of Cytochrome P450 3A4 and an Unknown P450 Enzyme.sup.1,2," Cancer Research, Aug. 1, 1994, vol. 54, No. 15, CNREA 8, Baltimore, MD, USA, pp. 4026-4035.
Clyde W. Wheeler et al., "Detection of Human Lung Cytochromes p450 That Are Immunochemically Related to Cytochrome P450IIE1 and Cytochrome P450IIIA," Biochemical Pharmacology, Jul. 7, 1992, vol. 44, No. 1, London, GB, pp. 183-186.
Guengerich et al., Chem. Res. Toxicol 4: 168-179 (1991).
Guengerich et al., Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research, pp.161-186 (Springer Verlag 1994).
Park et al., Biochemical Pharmacology 35(17): 2859-2867 (1986).
Ladona et al., Biochemical Pharmacology 37(24): 4735-4741 (1988).
Barnes et al., Biochem. J. 248: 301-304 (1987).
Beaune et al., Biochemical Pharmacology 34(19): 3547-3552 (1985).
Ko et al., Cancer Research 47: 3101-3109 (Jun. 15, 1987).
Buters et al., Drug Metabolism & Disposition 22(5): 688-692 (1994).
Gelboin, Pharmacological Reviews 45(4):413-453 (1993).
Gelboin Harry V.
Gonzalez Frank J.
Hutzell Paula K.
The United States of America as represented by the Department of
Ungar Susan
LandOfFree
Inhibitory and non-inhibitory antigen binding polypeptides again does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitory and non-inhibitory antigen binding polypeptides again, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitory and non-inhibitory antigen binding polypeptides again will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-315785