PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers

Details PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers

1998-06-04

1999-08-17

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514456, 5147721, 549335, A61K 31335, A61K 4734, C07D31908

Patent

active

059394536

ABSTRACT:
PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents, especially when the POE block(s) contain at least one unit containing an .alpha.-hydroxy acid.

REFERENCES:
patent: 4304767 (1981-12-01), Heller et al.
patent: 4532335 (1985-07-01), Helwing
patent: 4946931 (1990-08-01), Heller et al.
patent: 4957998 (1990-09-01), Heller et al.
patent: 5133739 (1992-07-01), Bezwada et al.
patent: 5412072 (1995-05-01), Sakurai et al.
patent: 5449513 (1995-09-01), Yokoyama et al.
patent: 5510103 (1996-04-01), Yokoyama et al.
patent: 5518730 (1996-05-01), Fuisz
patent: 5620697 (1997-04-01), Tormala et al.
patent: 5622718 (1997-04-01), Al-Shamkhani et al.
patent: 5626862 (1997-05-01), Brem et al.
patent: 5651986 (1997-07-01), Brem et al.
patent: 5693751 (1997-12-01), Sakurai et al.
R. Duncan et al., "The role of polymer conjugates in the diagnosis and treatment of cancer", STP Pharma Sciences, 6(4), 237-263 (1996).
J. Heller, "Poly(ortho esters)", Adv. Polymer Sci., 107, 41-92 (1993).
G.S. Kwon et al., "Block copolymer micelles as long-circulating drug vehicles", Adv. Drug Delivery Rev., 16, 295-309 (1995).
W.N.E. Wolthuis et al., "Synthesis and characterization of poly(ethylene glycol) poly(L-lactide) block copolymers", Third Eur. Symp. Controlled Drug Delivery, 271-276 (1994).
L. Youxin et al., "Synthesis and properties of biodegradable ABA triblock copolymers . . . ", J. Controlled Release, 27, 247-257 (1993).

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