Naphthyridines which affect IL-4 and G-CSF

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546122, 546143, A61K 31435, C07D47104

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active

059394315

ABSTRACT:
Compounds of formula ##STR1## or pharmaceutically acceptable salts thereof, wherein E, Q, T, U, V, L, Z, X, W, M, Y and Y' are as set forth herein, are described. These compounds are useful as agents in the treatment of allergy, inflammation, autoimmune diseases, B-cell lymphomas, tumors, and the after effects of bone marrow transplantation.

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Demetri et al, Blood, 78 (1991), pp. 2791-2808.
"FICOLL-PAQUE for in vitro isolation of lymphocytes", Pharmacia booklet.
de Zwart et al, J. Med. Chem., 32 (1989), pp. 487-493.
de Zwart et al, J. Med. Chem., 31 (1988), pp. 716-722.
Chemical Abstracts, 61, 7 (1964), abstract 8285c.

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