Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-12-17
1999-08-17
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514275, 514326, 514340, 514378, 514380, 544333, 546209, 5462721, 548240, 548243, 548244, 548245, A61K 31505, A61K 3142, C07D41306
Patent
active
059394188
ABSTRACT:
Isoxazolines, isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds, and methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders. The compounds can be represented by the formula: ##STR1## where X is O, S or NR.sup.15.
REFERENCES:
patent: 4454211 (1984-06-01), Takasu et al.
patent: 4819057 (1989-04-01), Naito et al.
patent: 5068241 (1991-11-01), Fuchs et al.
patent: 5070098 (1991-12-01), Fuchs et al.
patent: 5086183 (1992-02-01), Fuchs et al.
patent: 5095029 (1992-03-01), Kleefeld et al.
patent: 5162542 (1992-11-01), Fuchs et al.
patent: 5247094 (1993-09-01), Fuchs et al.
patent: 5380868 (1995-01-01), Gallenkamp et al.
patent: 5525622 (1996-06-01), Kanellakopulos et al.
CA 122: 31516 Dihydropyrazole compounds useful as insecticides. Salmon, Sep. 28, 1994.
Tamaki, et al; Matlystatins, New Inhibitors of Type IV Collagenases from Actinomadura atramentaria; J. of Antibiotics; Dec. 1994; pp. 1472-1480 and 1481-1492.
Robeva, et al; Synthetic and endogenous inhibitors of snake venom metalloproteinases; Biomed. Biochim Acta.; Dec. 1991; pp. 769-773.
McCullagh et al; Carboxyalky peptide derivatives; Chemical Abstracts; Jun. 24, 1995; Abstract No. 221199.
Hauptmann, et al; Comparison of the Anticoagulant and Antithrombotic Effects of Synthetic Thrombin and Factor Xa Inhibitors; Throm. Haemostasis; 1990; 63(2); pp. 220-223.
Stuerzebecher et al; Synthetic Inhibitors of Serine Proteinases XXIII. Inhibition of Factor Xa by Diamidines; Throm. Research; 1980; 17; pp. 545-548.
Tidwell, et al; Strategies for Anticoagulation with Synthetic Protease Inhibitors. Xa Inhibitors versus Thrombin Inhibitors; Throm Research; 1980; 19; pp. 339-349.
Stuerzebecher et al; Synthetic Inhibitors of Serine Proteinases Inhibition of Factor Xa by Derivatives of Benzamidine; Throm Research; 1976; 9; pp. 637-646.
Nagahara, et al; Dibasic (Amidinoaryl) propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors; J. Med. Chem.; 1997; 37; pp. 1200-1207.
Hauptmann et al; Anticoagulant potential of synthetic and recombinant inhibitors of factor Xa and thrombin in vitro; Blood Coagulation and Fibrinolysis; 1993; 4; pp. 577-582.
Galemmo, Jr. Robert Anthony
Pinto Donald J. P.
Pruitt James Russell
Quan Mimi Lifen
Stouten Petrus F. W.
Kerr Don M.
McKane Joseph
The DuPont Merck Pharmaceutical Company
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