Method of thrombin inhibition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 19, 530331, 560 34, 560 35, 560168, 560169, 563126, 563439, A61K 3806, C07K 508

Patent

active

059393920

ABSTRACT:
The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.

REFERENCES:
patent: 4346078 (1982-08-01), Bajusz et al.
patent: 4568636 (1986-02-01), Svendsen
patent: 4703036 (1987-10-01), Bajusz et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 5037819 (1991-06-01), Han
patent: 5110812 (1992-05-01), Han
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5260307 (1993-11-01), Ackermann et al.
patent: 5273982 (1993-12-01), Alig et al.
patent: 5583146 (1996-12-01), Kimball et al.
patent: 5705487 (1998-01-01), Schacht et al.
Jackson et al. "Pharmacological Assessment of the Antithrombotic Activity of the Peptide Thrombin Inhibitor. . . ", J. of Pharm. Exp. Ther. 261: 546-552, 1992.
Knabb et al. "In Vivo Characterization of a New Synthetic Thrombin Inhibitor", Thrombosis and Haemostasis, 67(1): 56-59, 1992.
Bajusz et al. "Inhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm," Chem. Abs. 99: 205609w, 1983.
Klement et al. "The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator Induced Thrombolysis in a Rat Model", Thrombosis and Haemostasis, 68(1): 64-68, 1992.
Marki et al., "The Anticoagulant and Antithrombotic Properties of Hirudins", Thrombosis and Haemostasis, 64(3): 344-348, 1990.
Broersma et al., "The Effect of Thrombin Inhibition in a Rat Arterial Thrombosis Model", Thrombosis Research, 64: 405-412, 1991.
Malek et al. "Palladium-catalyzed synthesis of Cinnamylamides", J. Org. Chem. 47(27): 5395-5397, 1982.
Malek, et al. Chem. Abs. 98: 16353, 1983.
Chung et al. J. Organic Chem. 1: 270-275.
Stewart et al: "Solid Phase Peptide Synthesis," Pierce Chemical Company, pp. 18-20 (with appendix).
Bajusz: "Interaction of Trypsin-like Enzymes With Small Inhibitors," pp. 277-298, Symposia Biologica Hungarica 25 (1984).
Persson et al. Thorax 47: 993-1000, 1992.
Salomonson et al. Am. Rev. Resp. Dis. 146: 1535-1542, 1992.
Markwardt et al. Biochem. Pharm. 23: 2247-2256, 1974.
Glusa et al. "The influence of benzamidine derivaties on human platelet function," Thrombosis et Diathesis Haemorrhagica 31: 172-178, 1974.
Anderson and Lok, J. Organic Chem. 37: 3953, 1972.
Fareed et al., Ann. N.Y. Acad. Sci. 370: 765-784, 1981.
Geratz, J.D. "Inhibition of thrombin, plasmin and plasminogen compounds," Thrombosis et Diathesis Halmorrhagica 23(3), 486-499, 1970.

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