Inhibition of proliferation of vascular smooth muscle cell

Details Inhibition of proliferation of vascular smooth muscle cell Inhibition of proliferation of vascular smooth muscle cell

1993-08-20

1998-10-13

Rories, Charles C. P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435375, 435377, 424450, 536 245, 536 243, 536 2431, 536 2433, A61K 4800, C12N 510

Patent

active

058212345

ABSTRACT:
This invention encompasses a method for inhibiting vascular cellular activity of cells associated with vascular lesion formation in mammals which involves administering an effective dosage of at least one antisense sequence to at least one gene expressing a cyclin or a cyclin dependent kinase which inhibits the expression of the gene. More particularly, the invention involves administering antisense sequences which inhibit the expression of cyclin A, B1, B2, C, D1, D2, D3, E or cyclin X (p46) cyclin X and cyclin dependent kinase cdc2, cdk2, cdk4 or cdk5. It is preferable to use two antisense sequences each from a different cyclin or cyclin dependent kinase. The cyclin or cyclin kinase depending kinase dosage is preferable administered in combination with proliferating cell nuclear antigen (PCNA). Antisense methods and compositions direct to inhibiting the expression of growth factors such as TGF-.beta..sub.1, TGF, bFGF, PDGF are also contemplated by the present invention.
The antisense sequences are incorporated into liposomes, particularly liposomes containing HVJ and which are directly administered intraluminally, intramurally or periadventitiously.
While the method of this invention are useful in treating a broad spectrum of vascular lesions such as lesions in the carotid femural and renal arteries, particularly lesions resulting from renal dialysis fistulas. The invention is particularly useful in treating vascular lesions associated with coronary artery angioplasty.

REFERENCES:
patent: 4149797 (1979-04-01), Imperial
patent: 5593974 (1997-01-01), Rosenberg et al.
Dzau, V. (1986) Hypertension 8:553-559.
Simons, M., et al. (1992) Nature 359:67-70.
Simons, M. and Rosenberg, R. (1992) Circulation Research 70:835-843.
Speir, E. and Epstein, S. (1992) Circulation 86:538-547.
Rainer, et al. (1991) Hypertension 18:326, abstract 47.
Itoh, et al. (1991) Hypertension 18:325, abstract 46.
Dzau, V. (1988) Circulation 77 (suppl I) 14-113.
Itoh, et al. (1990) J. Clin. Invest. 86:1690-1697.
Campbell-Boswell and Robertson (1981) Exp. and Mol. Pathology 35:265-276.
Naftilan, et al. (1989) Hypertension 13:706-711.
Itoh, et al. (1991) Biochem. Biophys. Res. Comm. 176:1601-1609.
Geisterfer, et al. (1988) Circulation Research 62:749-756.
Gibbons, et al. (1990) Clin. Research 38:287A.
Ferns, et al. (1991) Science 253:1129-1132.
Daemen, et al. (1991) Circulation Research 68:450-456.
Linder, et al. (1991) Circulation Research 68:106-113.
Majesky, et al. (1991) J. Clin. Invest. 88:914-910.
Sarzani, et al. (1989) J. Clin. Invest. 83:1404-1408.
Naftilan, et al. (1989) J. Clin. Invest. 83:1419-1424.
Powell, et al. (1989) Science 245:186-188.
Barret and Benditt (1988) P.N.A.S. 85:2810-2814.
Williams, Richart T. et al. "Identification of a Novel Cyclin-like Protein in Human Tumor Cells" J. Biol. Chem., vol. 268, No. 12, pp. 8871-8880, Apr. 25, 1993.
Ajchenbaum, Florence, et al. "Independent Regulation of Human D-type Cyclin Gene Expression during G.sub.1 Phase in Primary Human T Lymphocytes" J. Biol. Chem., vol. 268, No. 6, pp. 4113-4119, Feb. 25, 1993.
O'Connor, P.M., et al. "G.sub.2 Delay Induced by Nitrogen Mustard in Human Cells Affects Cyclin A/cdk2 and Cyclin B1/cdc2-Kinase Complexes Differently," J. Biol. Chem., vol. 268, No. 11, pp. 8298-8308, Apr. 15, 1993.
Kato, Keiko, et al. "Expression of Hepatitis B Virus Surface Antigen in Adult Rat Liver" J. Biol. Chem., vol. 266, No. 6, pp. 3361-3364, Feb. 25, 1991.
Rekhter, M. et al. "Cell Proliferation in Human Arteriovenous Fistulas Used For Hemodialysis" Arteriosclerosis and Thrombosis, vol. 13, No. 4 pp. 609-617 Apr., 1993.
B. Tseng et al. Cancer Gene Therapy, vol. 1, No. 1 (Mar. 1994) pp. 65-71.
C. Stein et al. Science, vol. 261, (Aug. 20, 1993) pp. 1004-1012.
P. Westermann et al. Biomed. Biochima. Acta, vol. 48, #1 ('89) pp. 85-93.
A. Thiery et al. in "Gene Regulation: Biology of Antisense RNA & DNA", ed. by R. Erickson et al., NY, Raven Press Ltd. ('92) pp. 147-161.
C. F. Bennett et al. J. Liposome Research, vol. 3, # 1 ('93) pp. 85-102.
R. Weiss, Science News, vol. 139 (Feb. 16, 1991) pp. 108-109.
M. Barinaga Science, vol. 265 (Aug. 5, 1994) p. 738.
B. Monia et al., J. Biol. Chem., vol. 267 (Oct. 5, 1992) pp. 19954-19962.
E. Wickstrom et al. The FASEB Journal, vol. 5 #5 (Mar. 15, 1991) p. A1443.
M. Ebbecke et al. Eur. Heart J., vol. 12, Abstr. Suppl., ('91) p. 11.
Y. Furukawa et al. Science, vol. 250 (Nov. 9, 1990) pp. 805-808.
D. Jaskulski et al Science, vol. 240 (Jun. 10, 1988) pp. 1544-1546.
P. Felques et al. PNAS, vol. 84 (Nov. '87) pp. 7413-7417.
R. Mannino et al. Bio/Techniques, vol. 6, #7 ('88) pp. 682-690.
J. Wang et al. Nature, vol. 343, (Feb. 8, 1990) pp. 555-557.
L. H. Tsai et al. Nature, vol. 353 (Sep. 12, 1991) pp. 174-177.
J. Pines Cell, vol. 58 (Sep. 8, 1989) pp. 833-846.
Y. Kaneda et al. Expt'l. Cell Res., vol. 173 ('87) pp. 56-69.
J. Holt et al. Mol. Cell. Biol., vol. 8 #2 (Feb. '88) pp. 963-973.
Life Technologies /GIBCO-BRL catalog, 1993-1994, Gaithersburg MD, pp. 9-19.
P. Hug et al., Biochem Biophys. Acta, vol. 1097 ('91) pp. 1-17.
A. Clowes et al. J. Cardiovasc. Pharmacology, vol. 14, Sep. 6 ('89) pp. 512-515.
P. Libby et al. Circulation, vol. 86, #6, Suppl.III (Dec. 1992) pp. III47-III52.
R. Mosley et al (abstract) Am. J. Gastroenterol., vol. 89, #10 (Oct. 1994) pp. 1874-1879.
D. Liu et al. (abstract) Clin. Exp. Hypertens., vol. 16 #4 (Jul. 1994) pp. 391-414.
E. Uhlmann et al. Chemical Reviews, vol. 90, #4 (Jun. '90) pp. 543-584.
E. Wickstrom et al., FASEB J. 5(5) (Mar. 15, 1991) A1443.
M. Ebbeske et al., Eur Heart J. 12 (Abstr. Suppl.) ('91) 11.
Y. Furukawa et al., Science 250 (Nov. 9, 1990) 805-808.
A. Clowes et al. J. Cardiovasc. Pharm. 14(Suppl. 6) (89) 512-515.
Y. Kaneda et al., Expt. Cell Res. 173 ('87) 56-69.
A. Lafont et al. Lancet 346 (Dec. 2, 1995) 1442-1443.
J. Milligan et al., J. Med. Chem. 36 (14) (Jul. 9, 1993) 1923-37.
M. Barinaga, Science 265 (Aug. 5, 1994) 738.
R. Weiss, Science News 139 (Feb. 16, 1991) 108-9.
C. Stein et al,. Science 261 (Aug. 20, 1993) 1004-12.
E. Uhlmann et al,. Chem. Res. 90 (4) (Jun. 1990) 543-84.
B. Tseng et al., Cancer Gene Ther. 1 (1) (Mar. 1994) 65-71.
P. Westermann et al. Biomed. Biochim. Acta 48(1) ('89) 85-93.

Affiliated with

Also associated with

Rating

Inhibition of proliferation of vascular smooth muscle cell does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of proliferation of vascular smooth muscle cell, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of proliferation of vascular smooth muscle cell will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-313351