Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-05-05
1998-10-13
Allen, Marianne P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 530399, A61K 3818, C07K 14475
Patent
active
058212230
ABSTRACT:
The present invention relates to a potent mitogenic growth factor called plasminogen-like growth factor (PLGF) isolated from conditioned medium of human lung fibroblasts. The protein has an apparent molecular weight under reducing conditions of 87 kDa and is structurally related to hepatocyte growth factor (HGF); however unlike HGF, which was reported to be specific for hepatic cells, PLGF stimulates a wide spectrum of target cells including melanocytes, endothelial cells and epithelial cells but excludes fibroblast cells.
The present invention further relates to recombinant cloned DNA fragments and expression cell systems expressing biologically active PLGF. The availability of purified PLGF as well as immunological and molecular probes should facilitate the study of proliferative disorders in which the factor plays an important role.
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patent: 5362716 (1994-11-01), Kmiecik et al.
T. Nakamura et al., "Molecular Cloning and Expression of Human Hepatocyte Growth Factor", Nature 342: 440-443 (1989).
K. Miyazawa et al., "Molecular Cloning and Sequence Analysis of cDNA For Human Hepatocyte Growth Factor", Biochem. and Biophys. Res. Comm. 163(2): 967-973 (1989).
Gohda, et al., "Purification and Partial Characterization of Hepatocyte Growth Factor from Plasma of a Patient with Fulminant Hepatic Failure", A.S.C.I., Feb. 1988, pp. 414-419.
Zarnegar, et al., "Purification and Biological Characterization of Human Hepatopoietin A, a Polypeptide Growth Factor for Hepatocytes", Cancer Research 49, Jun. 15, 1989, pp. 3314-3320.
Gherardi, et al., "Purification of Scatter Factor, a Fibroblast-Derived Basic Protein that Modulates Epithelial Interactions and Movement", Proc. Natl. Acad. Sci. USA, vol. 86, 1989, pp. 5844-5848.
Nakamura, et al., "Purification and Subunit Structure of Hepatocyte Growth Factor from Rat Platelets", Febs Letters, vol. 224, No. 2, 1987, pp. 311-316.
Aaronson Stuart A.
Chan Andrew M.-L.
Rubin Jeffrey S.
Allen Marianne P.
The United States of America as represented by the Department of
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