Anti-proliferation domain of a human Bcl-2 and DNA encoding the

Details Anti-proliferation domain of a human Bcl-2 and DNA encoding the Anti-proliferation domain of a human Bcl-2 and DNA encoding the

1996-05-23

1998-10-13

Kemmerer, Elizabeth C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530324, 536 235, 435325, C12N 1563, C12N 1512, A61K 3816

Patent

active

058210822

ABSTRACT:
A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO:13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.

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Theodorakis et al. Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1. Oncogene. vol. 12, pp. 1707-1713, Apr. 18, 1996.
Uhlmann et al. Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation. Cancer Research. vol. 56, pp. 2506-2509, Jun. 1, 1996.

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