Control of the synthesis of proteins by anitisense RNA-tRNA comp

Details Control of the synthesis of proteins by anitisense RNA-tRNA comp Control of the synthesis of proteins by anitisense RNA-tRNA comp

1994-11-28

1998-10-13

Elliot, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 29, 435 32, 4351723, 4352523, 4353201, 536 245, C12H 2100, C12N 1563, C12Q 102, C12Q 168

Patent

active

058210520

ABSTRACT:
The inhibition of proteins synthesis by an antisense RNA-tRNA complex which is capable of inhibiting translation is described. Under certain conditions, growth of organisms is inhibited by inhibition of non-specific translation by an antisense RNA construct to a tRNA target. In vitro, cell-free inhibition of viral protein translation is described. Transformed microorganisms are disclosed. The invention has applicability in the control of cell growth, such as viruses, bacteria, infected cells, or tumor cells. The invention is useful in animal and plant fields.

REFERENCES:
patent: 5245022 (1993-09-01), Weis et al.
patent: 5585479 (1996-12-01), Hoke et al.
Nakajima et al. "Organization and structure of an E. coli tRNA Operon . . . " Cell 23:239-249, Jan. 1991.
Norrander et al. "Construction of improved M13 vectors . . . " Gene 26:101-106, 1983.
Gewirtz et al. "Facilitating oligonucleoitde delivery: Helping antisnese deliver on its promise" Proc. Natl. acad. Sci. USA 93: 3161-3163, Apr. 1996.
Rojanasakul "Antisense oligonucleotide theraputics: Drug delivery and targeting" Adv. Drug Delivery Rev. 18: 116-131, 1996.
Oleg Mirochnitchenko and Masayori Inouye, "Evaluation of the Use of Antisense tRNA.sup.met as an Inhibitor for Eukaryotic Protein Synthesis", Antisense Research and Development, 3:171-179 (1993).

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