Transcutaneous in vivo activation of photosensitive agents in bl

Details Transcutaneous in vivo activation of photosensitive agents in bl Transcutaneous in vivo activation of photosensitive agents in bl

1995-02-02

1996-01-16

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514185, 514253, 514455, 514561, A61K 3141

Patent

active

054848032

ABSTRACT:
A method destroys or impairs target cells that have selectively accumulated a photosensitizing agent. The target cells are in the bloodstream of an intact animal, which bloodstream and animal further contain non-target cells. Radiation is applied transcutaneously to at least a portion of the intact animal at an intensity effective to impair or destroy selectively the target cells and to leave non-target cells relatively unimpaired. Target cells include leukemia cells, virus-containing cells, parasite-containing cells, and microorganisms such as bacteria, parasites and free viruses.

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Kessel et al., "Photosensitization by Synthetic Diporphyrins and Dichlorins in vivo AND in vitro", Photochem, Photobiol. 53(4):475-479 (1991).

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