Method for the stabilization of methionine-containing polypeptid

Details Method for the stabilization of methionine-containing polypeptid Method for the stabilization of methionine-containing polypeptid

1991-03-01

1993-12-21

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530399, C07K 1500, C07K 1700

Patent

active

052721353

ABSTRACT:
A method for inhibiting the oxidation of a polypeptide in a liquid or semi-solid pharmaceutical or therapeutic preparation, the polypeptides having an amino acid sequence comprising at least one methionine residue, wherein the amino acid methionine is added in a sufficient amount to inhibit the oxidation of the methionine residue(s) to methionine sulfoxide.

REFERENCES:
patent: 4835254 (1989-05-01), DiMarchi et al.
CA 100:144972z, Green Cross.
J. Parenteral Science and Technology, 42:1988, "Parenteral Formulations of Peptides, Proteins and Stabilizers", Chay et al., S3-S26.

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