Substituted cyclopentenes for the treatment of inflammation

Details Substituted cyclopentenes for the treatment of inflammation Substituted cyclopentenes for the treatment of inflammation

1994-07-15

1997-09-02

Carr, Deborah D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514678, 514680, 514684, 514825, 514916, 514602, 514709, 546184, 546192, 546195, 546203, 564426, 564427, 564 84, 568 34, A01N 4342

Patent

active

056631804

ABSTRACT:
A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein each of R.sup.1 and R.sup.2 is independently selected from alkyl, hydrido, hydroxyalkyl, halo, haloalkyl, alkoxycarbonyl and carboxyl; wherein R.sup.5 is selected from alkylsulfonyl, haloalkylsulfonyl and sulfamyl; and wherein B is phenyl or pyridyl, wherein B is optionally substituted at a substitutable position with alkyl, halo, alkylthio, cyano, haloalkyl, alkoxy, hydroxyalkyl and alkoxyalkyl; or a pharmaceutically-acceptable salt thereof.

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