System for solid phase reactions

Details System for solid phase reactions System for solid phase reactions

1992-10-06

1993-12-21

Therkorn, Ernest G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435174, 210657, 530334, 530344, 536 255, 536 256, C12N 900, C07H 1900, C07H 2100

Patent

active

052720756

ABSTRACT:
A rotating processor is disclosed. The apparatus includes a hollow enclosed rotor, a rotor drive, internal space to hold particulate porous reaction or separations media which may be porous, lines connecting the center and periphera of the internal space with the exterior through fluid line seals, valving to control fluid flow, gradient makers, and a microprocessor to control and monitor the entire system. Optionally the rotor may be spun with the axis vertical or horizontal, and may be used as a conventional column at rest. The rotating processor permits any synthetic or separative process utilizing particulate or solid phase supports, or separations involving phases of different density to be accomplished under conditions which facilitate precise control of fluid flow and minimization of both micro- and macro-anomalous flow. A computer-controlled flat multiport valve system is also described to facilitate programmed scheduling of reagents through the rotor.

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Abstract for Japan Patent No. 63-79895 Apr. 9, 1988.

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