Monoclonal antibodies specific for hirudin

Details Monoclonal antibodies specific for hirudin Monoclonal antibodies specific for hirudin

1992-07-27

1993-12-21

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 7021, 43524027, 436512, 436518, 436538, 53038825, 5303913, C12Q 100, G01N 3353, C07K 1528

Patent

active

052720594

ABSTRACT:
The invention concerns a process for the preparation of hybridoma cells which secrete monoclonal antibodies specific for hirudin, the hybridoma cells themselves, the monoclonal antibodies specific for hirudin secreted by these hybridoma cells, derivatives thereof, and a process for the preparation of said antibodies and derivatives. These monoclonal anti-hirudin antibodies and their derivatives are useful for the determination of hirudin and as an antidote to hirudin. The invention also concerns test kits and pharmaceutical compositions comprising said monoclonal antibodies and/or derivatives.

REFERENCES:
Hudson et al. Practical Immunology Blackwell Scientific Pub., Oxford, Great Britain 1976, pp. 2-5.
S. Spinner et al. J. Immunol., Methods 87, 79 (1986).
G. Stoffler et al., Thrombosis Research, Suppl. VII, 38 (1987).
S. Spinner et al. Biol. Chem. Hoppe-Seyler 367, Suppl. 254 (1986).
F. Scheffauer et al., Biol. Chem Hoppe-Seyler 367, Suppl., 255 (1986).
S. Spinner et al. Biol. Chem. Hoppe-Seyler 369, 921 (1988).
S. Spinner et al., Eur. J. Clin. Invest 18, A7 (1988).
S. Spinner et al., Thrombosis Research 51, 617 (1988).
S. J. T. Mao et al., J. Immunol. Methods 120, 45 (1989).

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