Immunoglobulins devoid of light chains

Details Immunoglobulins devoid of light chains Immunoglobulins devoid of light chains

1995-06-06

1999-02-23

Eisenschenk, Frank C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C07K 1600

Patent

active

058745416

ABSTRACT:
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.

REFERENCES:
Webster's II New Riverside University Dictionary, The Riverside Publishing Co./Houghton Mifflin Co., Boston MA, 1995.
Blier et al., "A Limited Number of B Cell Lineages Generates The Heterogeneity Of A Secondary Immune Response", J. Immunology, vol. 139, No. 12, pp. 3996-4006 (Dec. 15, 1987).
Hamers-Casterman et al., "Nature", 363:446-48 (1993).
Roitt et al., "Immunology", Gower Medical Publishing, London, pp. 1.5 and 5.7 (1985).
Ward et al., "Nature", 341:544-546 (1989).

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