Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1995-01-13
1997-09-02
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 6, 435 9131, 4351721, 4353201, 435325, 435410, 536 231, 536 232, 536 245, 514 44, C12Q 168, C12N 1585, C07H 2104
Patent
active
056630646
ABSTRACT:
Ribozyme having a ligand binding site formed as a double-stranded RNA and a single-stranded loop, the ribozyme having enzymatic activity to cleave and/or ligate itself or a separate RNA molecule.
REFERENCES:
patent: 5298612 (1994-03-01), Jennings et al.
patent: 5459015 (1995-10-01), Janjic et al.
patent: 5475096 (1995-12-01), Gold et al.
Altman et al., FASEB J. 7:7 (1993).
Anderson et al., "Mutagenesis of the hairpin ribozyme," Nucleic Acids Research 22:1096-1100 (1994).
Bartel et al., "HIV-1 Rev Regulation Involves Recognition of Non-Watson-Crick Base Pairs in Viral RNA," Cell 67:529-536 (1991).
Bartel and Szostak, "Isolation of New Ribozymes From a Large Pool of Random Sequences," Science 261:1411-1418 (1993).
Beaudry and Joyce, "Directed Evolution of an RNA Enzyme," Science 257:635-641 (1992).
Bertrand and Rossi, EBMO J. 13:2904 (1994).
Berzal-Herranz et al., "Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme," EBMO J. 12:2567-2574 (1993).
Berzal-Herranz et al., "In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed clevage and ligation reactions," Genes & Development 6:129-134 (1992).
Buzayan et al., "Nucleotide sequence and newly formed phosphodiester bond of spontaneously ligated satellite tobacco ringspot virus RNA," Nucleic Acids Research 14:9729-9743 (1986).
Carter, "Adeno-Associated Virus Vectors," Curr Opi. Biotech. 3:533-539 (1992).
Cech, "Ribozymes and Their Medical Implications," JAMA 260:3030-3034 (1988).
Cech, "Ribozyme Engineering," Current Opinion in Structural Biology 2:605-609 (1992).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589 (1992).
Chowrira et al., "Four Ribose 2'-Hydroxyl Groups Essential for Catalytic Function of the Hairpin Ribozyme," J. Biol. Chem. 268:19458-19462 (1993).
Chowrira et al., "In Vitro and in Vivo Comparison of Hammerhead, Hairpin, and Hepatitis Delta Virus Self-Processing Ribozyme Cassettes," J. Biol. Chem. 269:25856-25864 (1994).
Chowrira and Burke, "Binding and Cleavage of Nucleic Acids by the Hairpin Ribozyme," Biochemistry 30:8518 (1991) (from 208/154).
Chowrira et al., Biochemistry 32:1088 (1993).
Chowrira et al., Nature 354:320 (1991).
Chowrira and Burke, "Extensive Phosphorothioate Substitution Yields Highly Active and Nuclease-Resistant Hairpin Ribozymes," Nucleic Acids Res. 20:2835-2840 (1992).
Coetze et al., Genes & Develop. 8:1575 (1994).
Cohli et al., "Inhibition of HIV-1 Multiplication ini a Human CD4.sup.+ Lymphocytic Cell Line Expressing Antisense and Sense RNA Molecules Containing HIV-1 Packaging Signal and Rev Response Element(s)," Antisense Res. Dev. 4:19-26 (1994).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Feldstein et al., "Specific association between an endoribonucleolytic sequence from a satellite RNA and a substrate analogue containing a 2'-5'phosphodiester," Proc. Natl. Acad. Sci. USA 87:2623-2627 (1990).
Feldstein et al., "Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA," Gene 82:53-61 (1989).
Forster and Symons, "Self-Cleavage of Plus and Minus RNAs of a Virusoid and a Structural Model for the Active Sites," Cell 49:211-220 (1987).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Res. 21:2867-2872 (1993).
Guthrie, "Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein," Science 253:157-163 (1991).
Hampel et al., "The Hairpin Ribozyme," Methods: A Companion to Methods in Enzymology 5:37-42 (1993).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28:4929-4933 (1989).
Hampel et al., "Hairpin' Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Haseloff and Gerlach, Gene 82:43 (1989).
Herschlag et al. EBMO J. 13:2913 (1994).
Herschlag and Cech, "Catalysis of RNA Cleavage by the Tetrahymena thermophila Ribozyme 1. Kinetic Description of the Reaction of an RNA Substrate Complementary to the Active Site," Biochemistry 29:10159-10171 (1990).
Jellinek et al., "Inhibitions of Receptor Binding by High-Affinity RNA Ligands to Vascular Endothelial Growth Factor," Biochemistry 33:10450-10456 (1994).
Jenison et al., "High Resolution Molecular Discrimination by RNA", Science 263:1425-1429 (1994).
Joseph et al., "Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates," Genes & Development 7:130-138 (1993).
Joyce, "Directed Molecular Evolution," Scientific American 267:90-97 (1992).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
Kubik et al., "High-affinity RNA ligands to human .alpha.-thrombin," Nucleic Acids Research 22:2619-2626 (1994).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Leads to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," Embo J. 11:4411:4418 (1992).
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy for Gene Therapy in AIDS," Proc. Natl. Acad. Sci. U.S.A. 90:8000-8004 (1993).
Milligan and Uhlenbeck, "Synthesis of Small RNAs Using T7 RNA Polymerase," Methods Enzymol. 180:51-62 (1989).
Mohr et al., "A tyrosyl-tRNA synthetase can function similarly to an RNA structure in the Tetrahymena ribozyme," Nature 370:147-150 (1994).
Noller, Science 256:1416 (1992).
Ohkawa et al., "Activities of HIV-RNA Targeted Ribozymes Transcribed From a `Shot-Gun` Type Ribozyme-trimming Plasmid," Nucleic Acids Symp. Ser. 27:15-16 (1992).
Ojwang et al., "Inhibition of Human Immunodeficiency Virus Type 1 Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Ortigao et al., "Antisense Effects of Oligodeoxynucleotides with Inverted Terminal Internucleotidic Linkages: A Minimal Modification Protecting Against Nucleoytic Degradation," Antisense Research and Development 2:129-146 (1992).
Perreault et al., "Mixed Deoxyribo-and Ribo-Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Saldanha et al., FASEB J. 7:15 (1993).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222-1225 (1990).
Scanlon et al., "Ribozyme-Mediated Cleavage of c-fos mRNA Reduces Gene Expression of DNA Synthesis Enzymes and Metallothionein," Proc. Natl. Acad. Sci. USA 88:10591-10595 (1991).
Scaringe et al., "Chemical synthesis of biologically active oligoribonucleotides using .beta.-cyanoethyl protected ribonucleoside phosphoramidites," Nucl Acids Res. 18:5433-5441 (1990).
Sullenger and Cech, Science 262:1566 (1993).
Szostak, "In Vitro Genes," TIBS 17:89-93 (1993).
Taira et al., "Construction of a novel RNA-transcript-trimming plasmid which can be used both in vitro in place of run-off and (G)-free transcriptions and in vivo as multi-sequences transcription vectors," Nucleic Acids Research 19:5125-5130 (1991).
Tsuchihaschi et al., Science 262:99-102 (1993).
Uhlenbeck, "A Small
Burke John M.
Sargueil Bruno
LeGuyader John L.
University of Vermont
LandOfFree
Ribozymes with RNA protein binding site does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ribozymes with RNA protein binding site, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ribozymes with RNA protein binding site will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-307467