Method of inhibiting microvascular thrombosis

Details Method of inhibiting microvascular thrombosis Method of inhibiting microvascular thrombosis

1992-03-18

1994-01-04

Schein, Howard F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, C12N 900, C12N 700

Patent

active

052760154

ABSTRACT:
A method for reducing the thrombogenicity of microvascular anastomoses in a warm blooded mammal comprising administering to said mammal at the site of said microvascular anastomoses contemporaneously with microvascular reconstruction of a small but inhibitory effective amount of TFPI.

REFERENCES:
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Wun, J. Biol. Chem. 263, 6001-6004 (1988).
Day, Blood 76, 1538-1545 (1990).
Cooley & Hansen, Microsurgery 6, 46-48 (1985).
Cooley & Gould, Microsurgery 12, 281-287 (1991).
Salemark, Microsurgery 12, 308-311 (1991).
Rapaport, Blood 73, 359-365 (1989).
Broze et al., Biochemistry 29, 7539-7546 (1990).

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