Mutagenized DNA molecules encoding modified subunit a of Cholera

Details Mutagenized DNA molecules encoding modified subunit a of Cholera Mutagenized DNA molecules encoding modified subunit a of Cholera

1995-05-05

1999-02-23

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

43525233, 4352841, 4351723, 435325, 435909, 536232, C12N 100, C12N 510, C12N 121, C12N 1554

Patent

active

058742875

ABSTRACT:
The development of subunits and subunit analogs of the cholera exotoxin by recombinant DNA techniques provides vaccine products that can retain their biological activity and immunogenicity, and can confer protection against disease challenge. Genetically-engineered modifications of the subunits result in products that retain immunogenicity, yet are reduced in, or are essentially free of, enzymatic activity associated with toxin reactogenicity.

REFERENCES:
Jobling et al. "Analysis of the structure and function of cholera toxin A subunit." Abstracts of the 91st General Meeting of the American Society for Microbiology. B-205, Mar. 1, 1991.

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