Allergen-thymic hormone conjugates for treatment of IgE mediated

Details Allergen-thymic hormone conjugates for treatment of IgE mediated Allergen-thymic hormone conjugates for treatment of IgE mediated

1991-07-10

1994-01-04

Kim, Kay K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424 89, 424 92, 424 93A, 424 93D, 530301, 530365, 530370, 530379, 530395, 530397, 530399, 530402, 530403, 530404, 530405, 530406, 530408, 530409, 530410, 435174, 435177, A61K 3935, A61K 3936, A61K 3938, A61K 3724

Patent

active

052758141

ABSTRACT:
A protein conjugate or mixture useful in immunotherapy composed of a biological response modifier (BRM) and an allergen is disclosed. In use the protein conjugate or mixture is combined with a pharmaceutically acceptable carrier. Cytokines, bacterial, fungal and viral immunopotentiators and thymus hormones are disclosed as suitable BRM's for use in the invention.

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Goldstein et al (1972) "Purification and Biological Activity of Thymiosin a Hormone of the Thymus Gland" Proc. Natl. Acad. Sci USA 69(7):1800-1803.
Sztein et al (1986) "Modulation of Interleukin 2 Receptor Expression on Normal Human Lymphocytes by Thymic Hormones" Proc. Natl. Acad. Sci USA 83:6107-6111.
Serrate et al (1987) "Modulation of Human Natural Killer Cell Cytotoxicity Activity, . . . by Thymic Hormones" J. Immunology 139:2238-2343.

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