Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-03-29
2003-09-16
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S405000, C514S715000, C514S718000, C514S723000, C514S724000, C514S730000, C514S738000
Reexamination Certificate
active
06620418
ABSTRACT:
RELATED APPLICATION
This application claims the priority of Japanese Patent applications No. 11-087741 and No. 11-089072 filed on Mar. 30, 1999, and No. 2000-008746 filed on Jan. 18, 2000, which are incorporated herein by reference.
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a antiseptic/antifungal agent and an endermic liniment composition which contains it.
2. The Prior Art
Generally, an endermic liniment composition such as a cosmetic contains an antiseptic/antifungal agent (in the present specifications, “antiseptic” also means “antifungal” unless specified otherwise) such as paraoxy benzoate (so called parabens), salicylic acid, and sorbic acid and/or an antiseptic assistant such as phenoxy ethanol, for the purpose of improving the shelf life of the products by suppressing replication of microorganisms which contaminate the composition from outside and eventually killing off these microorganisms.
Antiseptic components such as paraben and/or antiseptic assistant components such as phenoxy ethanol have superior safety and efficacy when used as an antiseptic component in an endermic liniment composition. However, they still may cause irritation and such to a small number of very sensitive users.
Recently, endermic liniment compositions which are gentler to the skin are more in demand, and therefore the requirements of today's endermic liniment compositions are very difficult to meet by simply adding these parabens and phenoxy ethanol as the antiseptic components.
Of course it is possible to create an endermic liniment composition which does not have antiseptic components such as parabens or antiseptic assistant components such as phenoxy ethanol. However, in such a case, in order to ensure the antiseptic properties, the amount and/or the expiration date have to be limited or a complex means such as small subdivided containers or the backless mechanism has to be used, resulting in a tendency towards low economic benefits and versatility.
BRIEF SUMMARY OF THE INVENTION
Therefore, the object of the present invention is to provide a new antiseptic agent which has much superior safety and usability and can be blended into endermic liniment compositions, as well as an endermic liniment composition which contains it.
The inventors conducted earnest research to achieve the aforementioned object, and, as a result, discovered that 2,2-dialkyl-1,3-propanediol has a superior antiseptic effect and that it can be used as the effective ingredient of an antiseptic/antifungal agent. The inventors also discovered that an endermic liniment composition containing this antiseptic/antifungal agent has a superior antiseptic effect and that, even when the amount of parabens and/or phenoxy ethanol is substantially reduced, an anti septic properties adequate for normal use can be ensured. The inventors also discovered that, depending on the blend ratio of 2,2-dialkyl-1,3-propanediol, adequate antiseptic properties can be ensured in an endermic liniment composition without adding any parabens and/or phenoxy ethanol, thus completing the present invention.
That is, the present invention provides an antiseptic/antifungal agent in which 2,2-dialkyl-1,3-propanediol represented by the following general formula (I) is an effective component:
[In this formula, R
1
and R
2
can either be identical or different from each other, and both denote an alkyl group with a carbon number of 1-4.]
Also, the present invention provides an endermic liniment composition which contains the antiseptic agent of the present invention (hereafter referred to as “the endermic liniment composition of the present invention”).
As mentioned above, in the endermic liniment composition of the present invention, it is possible to use 2,2-dialkyl-1,3-propanediol represented by general formula (I) as essentially the only antiseptic agent.
The inventors conducted the aforementioned research, and, as a result, discovered that, by blending a combination of 3-methyl-3-methoxybutanol, which has been widely used as a solvent for perfumes, and 2-phenoxy ethanol, which has been widely used as an antiseptic assistant, or 1,2-pentanediol, which has been widely used as a humectant, a surprisingly superior antiseptic effect is manifested and that antiseptic properties adequate for normal use can be ensured even if the blend ratios of parabens and/or phenoxy ethanol are significantly reduced. That is, although there have been examples of use of both of these compounds, they have not been used together, and the present invention discovered that the combined use of these compounds manifests a superior antiseptic effect and ensures the antiseptic properties.
The inventors discovered in particular that, depending on the blend ratios when combining 3-methyl-3-methoxybutanol and 1,2-pentanediol, adequate antiseptic properties can be ensured without using any parabens, and verified that usability and safety were excellent, thus completing the present invention. That is, the present invention provides an endermic liniment composition, such as various cosmetics, containing 3-methyl-3-methoxybutanol and 1,2-pentanediol or 2-phenoxy ethanol, which has superior antiseptic properties as well as superior usability and safety.
DETAILED DESCRIPTION OF THE INVENTION
In this invention, “an endermic liniment composition” includes all compositions used for endermic use; for example it includes compositions which can be used widely in cosmetics such as foundation cosmetics, makeup cosmetics, hair cosmetics, etc. as well as in various drugs and/or quasi drugs such as ointments. The present invention also provides these modes of endermic liniment composition individually. In the present invention, “antiseptic” means resistance against all contaminating microorganisms such as bacteria, fungi, yeast, etc., and “antiseptic effectiveness” means protection against all these contaminating microorganisms. Therefore, even when only the word “antiseptic” is used in the present specifications, the concept of “antimildew” is not excluded.
Embodiments of the present invention are described below.
“The Invention Described in Claims 1-5”
A. The Effective Component of the Antiseptic Agent of the Present Invention and Specific Embodiments
2,2-dialkyl-1, 3-propanediol which is used as an effective component of the antiseptic agent of the present invention is a neopentyl-type 1,3-propanediol represented by the above formula (I) hereafter this 2,2-dialkyl-1,3-propanediol (I) is also referred to as “compound (I)”.
Different or identical alkyl groups with a carbon number of 1-4 which can be used for R
1
and R
2
include a methyl group, ethyl group, n-propyl group, isopropyl group, n-bbutyl group, isobutyl group, secondary butyl group, and tertiary butyl group.
Compound (I) is generally known as an prior art and has been disclosed in general engineering literature and/or patents in many forms. However, usually this is widely used as the raw material of urethane products and as a component of an insect repellent, and there has been no case where this was used as an effective component of an antiseptic agent.
Examples of compound (I) which are particularly superior in their antiseptic effect, less irritating, and superior in terms of usability of endermic liniments containing them include those whose R
1
and R
2
are a ethyl group, n-propyl group, isopropyl group, or n-butyl group (R
1
and R
2
can be either identical or different from each other). In particular, 2-n-butyl-2-ethyl-1,3-propanediol is easy to obtain and synthesize at the time of filing this application. Therefore, considering both the practical and economical aspects of implementation of the present invention, 2-n-butyl-2-ethyl-1,3-propanediol is superior as an effective component of the antiseptic agent of the present invention.
Compound (I) other than 2-n-butyl-2-ethyl-1,3-propanediol can also be prepared according to a prior art method, and such a product can be used for an effective component of the antiseptic agent of the present invention. Some examples of compound (I), i
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