Esters of alkoxy-acylderivatives of carnitine and pharmaceutical

Details Esters of alkoxy-acylderivatives of carnitine and pharmaceutical Esters of alkoxy-acylderivatives of carnitine and pharmaceutical

1974-06-28

1985-11-05

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560170, C07C10118, A61K 3122

Patent

active

045514771

ABSTRACT:
A novel class of esters of alkoxy-acylderivatives of carnitine, wherein the alkoxy-acyl radical has from 3 to 6 carbon atoms (typically: methoxyacetyl, methoxypropionyl, ethoxyacetyl, ethoxypropionyl and propoxyacetyl) is prepared by esterifying carnitine and then acylating the carnitine ester. Such esters are therapeutically useful in the treatment of cardiac disorders, hyperlipidaemias and hyperlipoproteinaemias.

REFERENCES:
patent: 3922340 (1975-11-01), Mewa
patent: 4194006 (1980-03-01), Cavazza
patent: 4237167 (1980-12-01), Cavazza
Wilson, "Textbook of Organic Medical and Pharmaceutical Chemistry," pp. 39-40 (1954).

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