Methods of alleviating convulsions and pain employing 4-aryloxy-

Details Methods of alleviating convulsions and pain employing 4-aryloxy- Methods of alleviating convulsions and pain employing 4-aryloxy-

1984-08-09

1985-11-05

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546141, A61K 3147, C07D21724, C07D40106

Patent

active

045514747

ABSTRACT:
This invention relates to 4-aryloxy-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl alkoxy and nitro; R is hydrogen and alkyl; R.sub.1 is hydrogen, alkyl, aralkyl, ##STR2## and CO.sub.2 R.sub.4 where R.sub.1 is aryl and alkyl; R.sub.2 and R.sub.3 are the same or differnt and are hydrogen and alkyl or R.sub.2 and R.sub.3 are fused together to form a pyrrolidino or a piperidino ring substituent; and m is an integer of 1 or 2; n is an integer of 2 or 3; and a pharmaceutically acceptable acid addition salt thereof.

REFERENCES:
patent: 3388130 (1968-06-01), Pesson
patent: 3457266 (1969-07-01), Gibas et al.
patent: 3629265 (1971-12-01), Grethe et al.
patent: 4059586 (1977-11-01), Mathison et al.
patent: 4113869 (1978-09-01), Gardner
Patent Abstracts of Japan, vol. 4, No. 2, 1/9/80, p. 122c.

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