Certain pyrrolyl-substituted hydroxamic acid derivatives

Details Certain pyrrolyl-substituted hydroxamic acid derivatives Certain pyrrolyl-substituted hydroxamic acid derivatives

1989-02-06

1990-10-02

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514427, 548537, 548561, A61K 3140, C07D20734, C07D207337

Patent

active

049607871

ABSTRACT:
The invention relates to the pyrrolyl-substituted hydroxamic acid derivatives of the formula ##STR1## wherein R represents aryl, aryl-lower alkyl, cycloalkyl, bicycloalkyl or adamantyl; R.sub.1 and R.sub.2 represent hydrogen or lower alkyl; Y represents a direct bond, lower alkylene, lower alkenylene or lower alkadienylene; Z represents ##STR2## wherein R.sub.3 represents hydrogen or acyl; R.sub.4 represents lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, aryl or aryl-lower alkyl; or Z represents ##STR3## wherein R.sub.3 represents hydrogen or acyl; R.sub.5 represents lower alkyl, C.sub.3 -C.sub.7 -cycloalkyl, aryl, aryl-lower alkyl, amino or N-(mono- or di-lower alkyl)-amino; R.sub.6 and R.sub.7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof provided that R.sub.3 represents hydrogen; which are useful as lipoxygenase inhibitors.

REFERENCES:
patent: 3952012 (1976-04-01), Carson
patent: 4769387 (1988-09-01), Summers et al.
patent: 4782085 (1988-11-01), Varma et al.
patent: 4792560 (1988-12-01), Huang
Argentieri FASEB J. 2(4) A369 (1988).
Summers et al., J. Med. Chem. vol. 30 pp. 574-580 (1987).
Artico et al., J. Med. Chem. vol. 31 pp. 802-806 (1988).
Jackson J. Med. Chem. vol. 31, No. 3 pp. 499 (1988).
Reynolds, Biochemical Pharmacology vol. 37 No. 23 pp. 4531-4537 (1988).
Summers et al., J. Med. Chem. vol. 31 pp. 1960-1964 (1988).

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