4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicami

Details 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicami 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicami

1987-01-28

1990-10-02

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514210, 514212, 5142358, 514255, 540598, 544121, 544357, 544359, 544360, 544366, A61K 31495, A61K 31445, C07D40112, C07D40312

Patent

active

049607766

ABSTRACT:
Novel 4-aryl-N-[2-(dialkylamino and heterocyclicamino)alkyl]-1-piperazinecarboxamides of the formula: ##STR1## wherein B is oxygen or sulfur; Ar is selected from ##STR2## or 2, 3 or 4-pyridyl; X is selected from hydrogen, halogen, loweralkyl, loweralkoxy, amino, dimethylamino, nitro, trifluoromethyl, cyano, acetyl, acetylamino, aminocarbonyl, carboxy or loweralkylcarboxylic acid ester; Y is selected from hydrogen, halogen, loweralkyl, loweralkoxy, nitro, trifluoromethyl, cyano, acetylamino, aminocarbonyl, carboxy or loweralkyl carboxylic acid ester; Z is selected from hydrogen, loweralkyl or loweralkoxy; Q is selected from ##STR3## m is 1 to 3 inclusive; n is zero or 1; p is zero to 3 inclusive; R.sup.1, R.sup.2 and R.sup.3 are loweralkyl and may be the same or different, or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom may be form a heterocyclic residue; and the pharmaceutically acceptable salts thereof are disclosed. The compounds are useful in a method of combating allergic response associated with anaphylactic sensitivity in animals and humans.

REFERENCES:
patent: 2642255 (1949-10-01), Morren
patent: 4308387 (1981-12-01), Bjork
patent: 4446133 (1984-05-01), Okazaki et al.
patent: 4593102 (1986-06-01), Shanklin, Jr.
patent: 4594343 (1986-06-01), Shanklin, Jr. et al.
patent: 4670456 (1987-06-01), Weber et al.
Ried et al., CA 93-114295a.

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