.alpha.S, 4S, 5R .alpha.-Amino-3-chloro-4-hydroxy-2-isoxazoline-

Details .alpha.S, 4S, 5R .alpha.-Amino-3-chloro-4-hydroxy-2-isoxazoline- .alpha.S, 4S, 5R .alpha.-Amino-3-chloro-4-hydroxy-2-isoxazoline-

1974-04-17

1976-03-16

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

195 29, 2602399, 260999, c07D26104

Patent

active

039445623

ABSTRACT:
Antibiotic U-43,795, producible by culturing Streptomyces sviceus in an aqueous nutrient medium has the following structure ##EQU1## The absolute configuration of U-43,795 was determined to be .alpha.S, 4S, 5R .alpha.-amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid. It is an amphoteric compound and can exist in different ionic forms according to the pH of the environment. At low pH, U-43,795 exists in the acid-addition salt form, at a higher pH in a zwitterion form, and at still higher pH in a metal salt form. U-43,795 inhibits the growth of Bacillus subtilis and Sarcina lutea, and can be used to inhibit such microorganisms in various environments.

REFERENCES:
patent: 3856807 (1974-12-01), Hanka et al.
Hanka et al. - C.A. 79, 100631f, (1973) - Abstract of Cancer Chemother. Rep., Part I (1973), 57(2), 141-147.
Martin et al. - Tetrahedron Lett. 1973, (27), 2549-2552.

Affiliated with

Also associated with

Rating

.alpha.S, 4S, 5R .alpha.-Amino-3-chloro-4-hydroxy-2-isoxazoline- does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .alpha.S, 4S, 5R .alpha.-Amino-3-chloro-4-hydroxy-2-isoxazoline-, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.S, 4S, 5R .alpha.-Amino-3-chloro-4-hydroxy-2-isoxazoline- will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-292049