Prodrugs for selective drug delivery

Details Prodrugs for selective drug delivery Prodrugs for selective drug delivery

1989-12-04

1995-06-27

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D40302, A61K 31495

Patent

active

054281636

ABSTRACT:
A broad class of pharmaceutical agents which react directly with electron carriers or with reactive species produced by electron transport to release a pharmacologically active molecule to effect a therapeutic functional change in the organism by a receptor or nonrecepter mediated action.

REFERENCES:
patent: 2829148 (1958-04-01), Chalkley
patent: 2839542 (1958-06-01), Chalkley
patent: 2839543 (1958-06-01), Chalkley
patent: 2855303 (1958-10-01), Chalkley
patent: 2936235 (1960-05-01), Chalkley
patent: 3798131 (1974-03-01), Rounds et al.
patent: 4399131 (1983-08-01), Durckheimer
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4626501 (1986-12-01), Landes
patent: 4656127 (1987-04-01), Mundy
patent: 4683194 (1987-07-01), Shiki et al.
patent: 4716106 (1987-12-01), Chiswell
Abuin, E., et al., Photochemistry and Photobiology, 30, 59-62 (1979).
Adam, W., et al, Photochemistry and Photobiology, 30, 45-48 (1979).
Adams, R., et al, "The Use of Oxalyly Chloride and Bromide for Producing Acid Chlorides, Acid Bromides or Acid Anhydrides", 599-611 (1920).
Agarwal, R. P., et al, Biochem. Pharmacol., 24, 693-701 (1975).
Agarwal, R. P., et al, Biochem. Pharmacol., 26, 359-367 (1977).
Allen, R. C., Chemical and Biological Generation of Excited States, 309-345 (1968).
Alston, T. A., et al, Biochemistry, 26, 4082-4085 (1987).
Ando, W., et al, Photochemistry and Photobiology, 30, 81-87 (1979).
Arakawa, H., et al, Chem. Pharm. Bull., 30(8), 3036-3039 (1982).
Asano, T., et al, Mol. Pharm., 13, 400-406 (1977).
Baker, B. R., "Design of Active-Site-Directed Irreversible Enzyme Inhibitors", 9 (1975).
Baker, B. R., et al, J. Med. Chem., 10, 682-685 (1967).
Baker, B. R., et al, J. Med. Chem., 10, 1101-1105 (1967).
Baker, B. R., et al, J. Med. Chem., 10, 1134-1138 (1967).
Baker, B. R., et al, J. Med. Chem., 11, 666-672 (1968).
Baldessarini, R. J., et al, Biochem. Pharmacology, 22, 247-256 (1973).
Baldwin, J. J., et al, J. Med. Chem., 18, 895-900 (1975).
Beard, N. A., et al, Br. J. Pharmac., 54, 65-74 (1975).
Bechara, E. J. H., et al, Photochemistry and Photobiology, 30, 101-110 (1979).
Becker, Y., Pharmac. Ther., 10, 119-159 (1980).
Berger, A. W., et al, Photochemistry and Photobiology, 4, 1123-1127 (1965).
Bergstrand, H., et al, Molecular Pharmacology, 13, 38-43 (1977).
Berridge, M. J. Ann. Rev. Biochem., 56, 159-193 (1987).
Bertelli, A., et al, Experientia, 32, 361-362 (1976).
Bloxham, D. P., Biochem. J., 147, 531-539 (1975).
Bogan, D. J., et al, "Formation and Chemiluminescent Decomposition of Dioxetanes in the Gas Phase", 3-15 (1979).
Borchardt, R. T., et al, J. Medicinal Chem., 18(3), 300-303 (1975).
Bowen, E. J., et al, ed., "Luminescence in Chemistry", 183-190 (1968).
Brady, R. O., Biochim. Biophys. Acta, 70, 467-468 (1963).
Bricker, L. A., et al, J. Biological Chem., 247(15), 4914-4915 (1972).
Brodbeck, U., ed., "Enzyme Inhibitors", 61-74 (1980).
Brodbeck, U., ed., "Enzyme Inhibitors", 223-224 (1980).
Bryan, L. E., et al, Antimicrob. Agents Chemother., 9(6), 928-938 (1976).
Burghuber, O. C., et al, Am. Rev. Respir. Dis., 131, 778-785 (1985).
Burr, J. G., "Chemi- and Bioluminescence", Marcel Dekker, Inc., N.Y., N.Y., 245-320 (1985).
Buu, N. T., et al, Br. J. Pharmac., 52, 401-406 (1974).
Carlin, S. C., et al, Mol. Pharm., 10, 194-203 (1974).
Catignani, G. L., et al, Life Sciences, 16, 1915-1922 (1975).
Chen, F. W. K., et al, Prostaglandins, 13, 115-125 (1977).
Chignard, M., et al, Prostaglandins, 14, 222-241 (1977).
Chiou, C. Y., et al, Br. J. Pharmac., 53, 279-285 (1975).
Coleman, J. E., J. Biol. Chem., 243(17), 4574-4587 (1968).
Collins, K. D., et al, J. Biol. Chem., 246(21), 6599-6605 (1971).
Collins, K. D., et al, J. Biol. Chem., 249(1), 136-142 (1974).
Counsell, R. E., et al, J. Medicinal Chem., 13(6), 1040-1042 (1970).
Coward, J. K., "Drug Action and Design: Mechanism-Based Enzyme Inhibitors", 13=27 (1979).
Cushman, D. W., et al, Biochimica et Biophysica Acta, 424, 449-459 (1976).
Dalton, C., et al, Prostaglandins, 7, 319-327 (1974).
DeClercq, E., et al, Life Sciences, 17, 187-194 (1975).
Deibel, Jr., M. R., et al, Biochemical Medicine, 25, 288-297 (1981).
Demain, A. L., Biochem. Soc. Symp., 48, 117-132 (1983).
Diliberto, Jr., E. J. et al, Biochemical Pharmacology, 22, 2961-1972 (1973).
D'Iorio, A., et al, Canadian J. of Biochemistry and Physiology, 41, 1779-1784 (1963).
Downing, D. T., et al, Biochem. Biophys. Research Comm., 40, 218-223 (1970).
Dreyer, J. F., "Self-Attenuating Ophthalmic Filter", Report WADD-TR-60-632, Feb. 1961, AD 322820.
Dreyer, J. F., Polacoat Inc., Tech. Report SEG-TR-65-50, 1-40, Oct. 1965.
Dreyer, J. F. Polacoat Inc., WADD Tech. Report 60-827, Contract AF 33(616)-6715, 1-20, Feb. 1961.
Dreyer, J. F., Reprint from J. Phys. and Colloid Chem., 52(5), 809-810 (1948).
Dreyer, J. F., unpublished paper presented at the Vth Intern'l Liquid Crystal Conf., in Stockholm, Sweden, Jun. 20, 1974.
Duggan, D. E., et al, J. Med. Chem., 18(9), 900-905 (1975).

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