Imidazole and 1,2,4-triazole derivatives with angiotensin II ant

Details Imidazole and 1,2,4-triazole derivatives with angiotensin II ant Imidazole and 1,2,4-triazole derivatives with angiotensin II ant

1994-02-10

1995-02-14

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514382, 514397, 514307, 548250, 548252, 548253, 548254, 5483121, 546144, A61K 3141, A61K 31415, C07D25704

Patent

active

053896610

ABSTRACT:
This invention relates to novel substituted imidazole and triazole derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods of making the compounds, novel intermediates useful in the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of using them are also covered.

REFERENCES:
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 5128355 (1992-07-01), Carini et al.
patent: 5138069 (1992-08-01), Carini et al.
CA 91:206563y The indentification . . . determinations, Inglis et al., p. 271, 1979.
CA 113:23919x Imidazolidine-2,4-dione . . . antagonists, Hemmi et al., p. 663, 1990.

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