Substituted pyrano[4,3-d]-thiazolo[3,2-a]pyrimidines

Details Substituted pyrano[4,3-d]-thiazolo[3,2-a]pyrimidines Substituted pyrano[4,3-d]-thiazolo[3,2-a]pyrimidines

1978-03-24

1978-12-05

Curtis, Allen B.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424246, 542449, 544 34, 544252, A61K 3118, C07D40514

Patent

active

041286480

ABSTRACT:
2,3,8,9-Tetrahydro-5H,6H-pyrano[4,3-d]thiazolo[3,2-a]pyrimidines of the structure ##STR1## are provided wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, halogen, cyano, carbethoxy, carboxyl, trifluoromethyl or lower alkoxy, and n is 2 or 3, and m is 0 to 2. These compounds are useful in the treatment of auto-immune disorders, such as rheumatoid arthritis.

REFERENCES:
patent: 3636041 (1972-01-01), Schmidt et al.
patent: 3657245 (1972-04-01), Bormann et al.
Khodzhibaev et al., "Reaction of CO with 4-Me-5-carbethoxy-2-aminothiazole," in Chem. Abs. 85:21277r, 1976, vol. 85, p. 21285.

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