Solubilization of Rafoxanide

Details Solubilization of Rafoxanide Solubilization of Rafoxanide

1978-02-13

1978-12-05

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

424324, A61K 3179, A61K 31165

Patent

active

041286324

ABSTRACT:
A soluble complex of an insoluble drug, exemplified by Rafoxanide is formed with polyvinylpyrrolidone and water. The complex is formed by combining the insoluble drug and polyvinylpyrrolidone in a suitable water miscible organic solvent, preferably acetone or glycerolformal, and water. The complex is formed in situ. The solvent may be removed, if desired, and the complex remains in aqueous solution. The aqueous solution is then suitable for injection and may be used to treat fasciola or liver fluke infections.

REFERENCES:
nessel - Chem. Abst., vol. 84 (1976), p. 111, 680a.

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