Fluorescence polarization assay for cyclosporin A and metabolite

Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase

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436501, 436546, 436805, 436815, 530321, G01N 3352, G01N 3353, G01N 3358, G01N 3368

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active

054279607

ABSTRACT:
The present invention is directed to a fluorescence polarization immunoassay for cyclosporin A and metabolites thereof. The present invention also relates to novel cyclosporin A derivative compounds useful in fluorescence polarization techniques. Included among the novel compounds are cyclosporin A derivatives where the amino acid in the first position is altered. The cyclosporin A derivatives are useful in forming immunogens for raising antibodies specific to cyclosporin A and metabolites thereof.

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