Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Reexamination Certificate
2000-04-28
2002-07-30
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
C424S400000, C424S455000, C424S456000, C424S457000, C424S463000
Reexamination Certificate
active
06426089
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a multi-layered soft capsule for eliminating bad breath, having capsule-in-capsule structure (that is called a multiple structure) and effectively eliminating bad breath.
BACKGROUND ART
Hitherto, oral compositions which are (orally) administered to eliminate bad breath in an oral cavity have been studied for a long period of time, as described in for example Japanese Patent Kokai Publication Hei 3(1991)-220117, and some of them are commercially available. Among them, there may be one effectively eliminating not only normal foul halitosis such as mercaptan odor, but also odor generated by a certain food, including garlic odor (particularly, diarylsulfide odor) and alcoholic odor, because it contains some components for eliminating bad breath.
However, the oral compositions conventionally available do not totally eliminate bad breath originated from the ingested food.
The bad breath is generally believed to be caused by a mixture of odor which is generated in an oral cavity from ingested food, with odor which is returned to the oral cavity from a stomach after digesting food, that is usually called as “returned odor”. Therefore, even if the former odor in an oral cavity is eliminated, the bad breath remains because of the presence of the returned odor, generated in a stomach.
In order to completely eliminate bad breath, an administration of at least two types of oral compositions, such as one for eliminating the former odor in the oral cavity and another one for eliminating the latter odor originated from the ingested food (that is “the returned odor”) is necessary. However, this was inconvenient and also had a disadvantage that, since the latter composition is also dissolved and masticated together with the former composition in the oral cavity, it is thinned by mixing with saliva and other peptic juice before it reaches the stomach, and the content of effective components is too low to eliminate.
One object of the present invention is to overcome the disadvantage and to provide a capsule for eliminating bad breath, particularly effectively acting to both the odor in the oral cavity and the returned odor form the stomach.
Disclosure Of Invention
As shown in
FIG. 1
, a multi-layered soft capsule (
10
) for eliminating bad breath of the present invention comprises a first soft capsule composed of a first soft capsule layer (
1
) and a first soft capsule content (
3
), and a second soft capsule composed of a second soft capsule layer (
2
) and a second soft capsule content (
4
), which is contained in the first soft capsule. Both the contents (
3
) and (
4
) contain a component having an effect of eliminating bad breath. The multi-layered soft capsule (
10
) of the present invention is characterized in that a second soft capsule (
2
) is soluble in the stomach.
The present invention also provides a multi-layered soft capsule (
10
) of which the first and/or second soft capsule layer(s) (
1
) and /or (
2
) and/or the content(s) (
3
) and/or (
4
) comprises a flavoring component.
Additionally, the present invention provides a method for producing a multi-layered soft capsule for eliminating bad breath, comprising simultaneously extruding a composite jet stream into a cooling solution, wherein the composite jet stream consists of a second soft capsule filling solution extruded through a first nozzle, a second soft capsule layer-forming solution though a second nozzle, a first soft capsule filling solution extruded through a third nozzle and a first soft capsule layer-forming solution extruded through a fourth nozzle, with the first, second, third and fourth nozzles being arranged concentrically, a diameter of the nozzles gradually increasing in a numerical order.
Accordingly, the multi-layered soft capsule (
10
) of the present invention has two effects of eliminating bad breath, including an immediate effect (a) and a long-lasting effect (b) as explained below, by (oral) administration of one capsule.
(a) The component having an effect of eliminating odor in the oral cavity, which is contained in the first soft capsule content, can immediately eliminate the odor after oral administration (the immediate effect of eliminating bad breath). The first soft capsule layer and/or content encapsulated therein may also contain a flavoring component so that a bitter flavor and the like is sweetened when the capsule is dissolved and masticated in the oral cavity, and therefore, the multi-layered soft capsule has excellent palatability.
(b) The component encapsulated in the second soft capsule reaches the stomach without dissolving and masticating in the oral cavity, as well as without mixing with saliva, other peptic juice and the like, and then dissolves in a stomach to show an effect of eliminating “returned odor” (the long-lasting effect of eliminating bad breath).
BEST MODE FOR CARRYING OUT THE INVENTION
The present invention will briefly be explained as follows.
As shown in
FIG. 1
, a multi-layered soft capsule (
10
) for eliminating bad breath of the present invention comprises a first soft capsule and a second soft capsule encapsulated in the first soft capsule. The first soft capsule is composed of a first soft capsule layer (
1
) and a first soft capsule content (
3
) containing a component having an effect of eliminating bad breath, wherein the first soft capsule content (
3
) is encapsulated in the first soft capsule layer (
1
). The second soft capsule is composed of a second soft capsule layer (
2
) and a first soft capsule content (
4
) containing a component having an effect of eliminating bad breath, wherein the second soft capsule content (
4
) is encapsulated in the second soft capsule layer (
2
).
A base material for forming the first and second soft capsule layers is not specifically limited as long as it forms a soft capsule layers but including gelatin, agar, or a mixture thereof.
In addition to the base material mentioned above, the material for forming the first and second soft capsule layers of a multi-layered soft capsule according to the present invention may also contain a water-soluble polyol such as sotitol, glycerin and the like, sodium alginate or low methoxyl pectin or one obtained by gelling an aqueous solution of sodium alginate or low methoxyl pecting with a polyvalent ion, preferably bi- or more valent ion or the like. The polyvalent ion can be a salt of polyvalent metal such as bi- or more valent metal, particularly when gelling the aqueous solution of sodium alginate, a water-soluble calcium salt, such as calcium chlorate, calcium phosphate and the like is suitably used, or when gelling low methoxyl pectin, a water-soluble salt, such as calcium, magnesium or the like is suitably used.
In the present invention, the material for forming the first and second soft capsule layers may further contain a flavoring component. The flavoring component includes a sweetening, an acidulant and a bitter flavoring. An example of the sweetening may be aspartame, stevia, saccharin sodium, thaumatin. An example of the acidulant may be citric acid, malic acid, tartaric acid, fumaric acid, An example of the bitter flavoring may be caffeine, naringin. At least one selected from the sweetening, the acidulant and the bitter flavoring may be employed in the layer of the first and second soft capsule as the flavoring component.
The material for forming the first and second soft capsule layers of the multi-layered soft capsule according to the present invention may further contain an adjuvant such as a plasticizer, a preservative, a colorant and a perfume, and the like.
A total amount of the adjuvant and the flavoring component formulated in the material for forming the first and second soft capsule layers may be 0.1 to 50 parts by weight, based on 100 parts by weight of the material for forming the first and second soft capsule layers. Preferably, the flavoring component may be in an amount of 0.1 to 30 parts by weight based on 100 parts by weight of the material.
In order to make the second soft capsule insoluble in an oral cavit
Kagawa Masaru
Kamaguchi Ryosei
Miura Yuko
Nishikawa Masashi
Sunohara Hideki
Evans Charesse L.
Kishore Gollamudi S.
Merchant & Gould P.C.
Morishita Jintan Co., Ltd.
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