2-Heterocyclylalkyl-6-methoxy-naphthalenes

Details 2-Heterocyclylalkyl-6-methoxy-naphthalenes 2-Heterocyclylalkyl-6-methoxy-naphthalenes

1978-11-21

1981-01-06

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424858, 424250, 544 582, 544 59, 544174, 544383, 544387, 544390, 544391, 544398, C07D24104, C07D27500, A61K 3154, A61K 31495

Patent

active

042436656

ABSTRACT:
Compounds corresponding to the formula ##STR1## in which R' is a hydrogen atom or a methyl radical and R represents a radical ##STR2## in which Z is O, S, S.fwdarw.O, SO.sub.2 or NR.sub.1, in which R.sub.1 is a hydrogen atom or an alkyl, CONR.sub.2 R.sub.3, COOR.sub.2, COR.sub.2 or SO.sub.2 R.sub.2 radical, R.sub.2 and R.sub.3 each representing, independently of one another, a hydrogen atom, an alkyl radical having 1 to 4 carbon atoms, a phenyl radical or a CF.sub.3 radical, in the form of racemates or enantiomers if R' is CH.sub.3, and also, where appropriate, their addition salts with pharmaceutically acceptable acids.
The compounds and salts are useful as anti-inflammatory agents, e.g. for treatment of arthritis. A process for preparing them and pharmaceutical compositions containing them are also claimed.

REFERENCES:
patent: 2724713 (1955-11-01), Goldman
patent: 2858312 (1958-10-01), Olin
patent: 3239528 (1966-03-01), Bebenburg et al.
patent: 3935214 (1976-01-01), Zellner
patent: 4125612 (1978-11-01), Sherlock

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